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Apramycin susceptibility of multidrug-resistant Gram-negative blood culture isolates in five countries in Southeast Asia.
Gysin M, Hon PY, Tan P, Sengduangphachanh A, Simmalavong M, Hinfonthong P, Kaewphanderm N, Pham TD, Nguyen TH, Haldimann K, Becker K, van Doorn HR, Hopkins J, Simpson AJH, Ashley EA, Kesteman T, Tran HH, Vasoo S, Ling CL, Roberts T, Turner P, Hobbie SN. Gysin M, et al. Among authors: hobbie sn. Int J Antimicrob Agents. 2022 Oct;60(4):106659. doi: 10.1016/j.ijantimicag.2022.106659. Epub 2022 Aug 18. Int J Antimicrob Agents. 2022. PMID: 35988665 Free article.
In vitro activity of apramycin against multidrug-, carbapenem- and aminoglycoside-resistant Enterobacteriaceae and Acinetobacter baumannii.
Juhas M, Widlake E, Teo J, Huseby DL, Tyrrell JM, Polikanov YS, Ercan O, Petersson A, Cao S, Aboklaish AF, Rominski A, Crich D, Böttger EC, Walsh TR, Hughes D, Hobbie SN. Juhas M, et al. Among authors: hobbie sn. J Antimicrob Chemother. 2019 Apr 1;74(4):944-952. doi: 10.1093/jac/dky546. J Antimicrob Chemother. 2019. PMID: 30629184 Free PMC article.
Apralogs: Apramycin 5-O-Glycosides and Ethers with Improved Antibacterial Activity and Ribosomal Selectivity and Reduced Susceptibility to the Aminoacyltranserferase (3)-IV Resistance Determinant.
Quirke JCK, Rajasekaran P, Sarpe VA, Sonousi A, Osinnii I, Gysin M, Haldimann K, Fang QJ, Shcherbakov D, Hobbie SN, Sha SH, Schacht J, Vasella A, Böttger EC, Crich D. Quirke JCK, et al. Among authors: hobbie sn. J Am Chem Soc. 2020 Jan 8;142(1):530-544. doi: 10.1021/jacs.9b11601. Epub 2019 Dec 17. J Am Chem Soc. 2020. PMID: 31790244 Free PMC article.
Predictive Analysis of the Side Chain Conformation of the Higher Carbon Sugars: Application to the Preorganization of the Aminoglycoside Ring 1 Side Chain for Binding to the Bacterial Ribosomal Decoding A Site.
Pirrone MG, Gysin M, Haldimann K, Hobbie SN, Vasella A, Crich D. Pirrone MG, et al. Among authors: hobbie sn. J Org Chem. 2020 Dec 18;85(24):16043-16059. doi: 10.1021/acs.joc.0c01836. Epub 2020 Sep 23. J Org Chem. 2020. PMID: 32902280 Free PMC article.
An Advanced Apralog with Increased in vitro and in vivo Activity toward Gram-negative Pathogens and Reduced ex vivo Cochleotoxicity.
Sonousi A, Quirke JCK, Waduge P, Janusic T, Gysin M, Haldimann K, Xu S, Hobbie SN, Sha SH, Schacht J, Chow CS, Vasella A, Böttger EC, Crich D. Sonousi A, et al. Among authors: hobbie sn. ChemMedChem. 2021 Jan 19;16(2):335-339. doi: 10.1002/cmdc.202000726. Epub 2020 Oct 23. ChemMedChem. 2021. PMID: 33007139 Free PMC article.
Efficacy of EBL-1003 (apramycin) against Acinetobacter baumannii lung infections in mice.
Becker K, Aranzana-Climent V, Cao S, Nilsson A, Shariatgorji R, Haldimann K, Platzack B, Hughes D, Andrén PE, Böttger EC, Friberg LE, Hobbie SN; ENABLE consortium. Becker K, et al. Among authors: hobbie sn. Clin Microbiol Infect. 2021 Sep;27(9):1315-1321. doi: 10.1016/j.cmi.2020.12.004. Epub 2020 Dec 11. Clin Microbiol Infect. 2021. PMID: 33316399 Free article.
Synthesis and Antibacterial Activity of Propylamycin Derivatives Functionalized at the 5''- and Other Positions with a View to Overcoming Resistance Due to Aminoglycoside Modifying Enzymes.
Lubriks D, Zogota R, Sarpe VA, Matsushita T, Sati GC, Haldimann K, Gysin M, Böttger EC, Vasella A, Suna E, Hobbie SN, Crich D. Lubriks D, et al. Among authors: hobbie sn. ACS Infect Dis. 2021 Aug 13;7(8):2413-2424. doi: 10.1021/acsinfecdis.1c00158. Epub 2021 Jun 11. ACS Infect Dis. 2021. PMID: 34114793 Free PMC article.
61 results