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632 results

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Page 1
Epigenetic drug discovery: targeting DNA methyltransferases.
Foulks JM, Parnell KM, Nix RN, Chau S, Swierczek K, Saunders M, Wright K, Hendrickson TF, Ho KK, McCullar MV, Kanner SB. Foulks JM, et al. Among authors: ho kk. J Biomol Screen. 2012 Jan;17(1):2-17. doi: 10.1177/1087057111421212. Epub 2011 Sep 30. J Biomol Screen. 2012. PMID: 21965114 Review.
Discovery of 4-phenyl-2-phenylaminopyridine based TNIK inhibitors.
Ho KK, Parnell KM, Yuan Y, Xu Y, Kultgen SG, Hamblin S, Hendrickson TF, Luo B, Foulks JM, McCullar MV, Kanner SB. Ho KK, et al. Bioorg Med Chem Lett. 2013 Jan 15;23(2):569-73. doi: 10.1016/j.bmcl.2012.11.013. Epub 2012 Nov 16. Bioorg Med Chem Lett. 2013. PMID: 23232060
Pharmacologic activation of PKM2 slows lung tumor xenograft growth.
Parnell KM, Foulks JM, Nix RN, Clifford A, Bullough J, Luo B, Senina A, Vollmer D, Liu J, McCarthy V, Xu Y, Saunders M, Liu XH, Pearce S, Wright K, O'Reilly M, McCullar MV, Ho KK, Kanner SB. Parnell KM, et al. Among authors: ho kk. Mol Cancer Ther. 2013 Aug;12(8):1453-60. doi: 10.1158/1535-7163.MCT-13-0026. Epub 2013 May 29. Mol Cancer Ther. 2013. PMID: 23720766
A small-molecule inhibitor of PIM kinases as a potential treatment for urothelial carcinomas.
Foulks JM, Carpenter KJ, Luo B, Xu Y, Senina A, Nix R, Chan A, Clifford A, Wilkes M, Vollmer D, Brenning B, Merx S, Lai S, McCullar MV, Ho KK, Albertson DJ, Call LT, Bearss JJ, Tripp S, Liu T, Stephens BJ, Mollard A, Warner SL, Bearss DJ, Kanner SB. Foulks JM, et al. Among authors: ho kk. Neoplasia. 2014 May;16(5):403-12. doi: 10.1016/j.neo.2014.05.004. Epub 2014 Jun 18. Neoplasia. 2014. PMID: 24953177 Free PMC article.
Discovery of novel quinolinone adenosine A2B antagonists.
McGuinness BF, Ho KK, Stauffer TM, Rokosz LL, Mannava N, Kultgen SG, Saionz K, Klon A, Chen W, Desai H, Rogers WL, Webb M, Yin J, Jiang Y, Li T, Yan H, Jing K, Zhang S, Majumdar KK, Srivastava V, Saha S. McGuinness BF, et al. Among authors: ho kk. Bioorg Med Chem Lett. 2010 Dec 15;20(24):7414-20. doi: 10.1016/j.bmcl.2010.10.030. Epub 2010 Nov 4. Bioorg Med Chem Lett. 2010. PMID: 21055932
2-Benzimidazolyl-9-(chroman-4-yl)-purinone derivatives as JAK3 inhibitors.
Cole AG, Bohnstedt AC, Paradkar V, Kingsbury C, Quintero JG, Park H, Lu Y, You M, Neagu I, Diller DJ, Letourneau JJ, Shao Y, James RA, Riviello CM, Ho KK, Lin TH, Wang B, Appell KC, Sills M, Quadros E, Kimble EF, Ohlmeyer MH, Webb ML. Cole AG, et al. Among authors: ho kk. Bioorg Med Chem Lett. 2009 Dec 1;19(23):6788-92. doi: 10.1016/j.bmcl.2009.09.080. Epub 2009 Sep 25. Bioorg Med Chem Lett. 2009. PMID: 19836234
Identification and hit-to-lead optimization of a novel class of CB1 antagonists.
Letourneau JJ, Jokiel P, Olson J, Riviello CM, Ho KK, McAleer L, Yang J, Swanson RN, Baker J, Cowley P, Edwards D, Ward N, Ohlmeyer MH, Webb ML. Letourneau JJ, et al. Among authors: ho kk. Bioorg Med Chem Lett. 2010 Sep 15;20(18):5449-53. doi: 10.1016/j.bmcl.2010.07.091. Epub 2010 Jul 25. Bioorg Med Chem Lett. 2010. PMID: 20719511
632 results