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Blocking Site-Specific Cleavage of Human Tau Delays Progression of Disease-Related Phenotypes in Genetically Matched Tau-Transgenic Mice Modeling Frontotemporal Dementia.
J Neurosci. 2022 Jun 8;42(23):4737-4754. doi: 10.1523/JNEUROSCI.0543-22.2022. Epub 2022 May 4.
J Neurosci. 2022.
PMID: 35508385
Free PMC article.
Caspase-2 cleavage of tau reversibly impairs memory.
Zhao X, Kotilinek LA, Smith B, Hlynialuk C, Zahs K, Ramsden M, Cleary J, Ashe KH.
Zhao X, et al.
Nat Med. 2016 Nov;22(11):1268-1276. doi: 10.1038/nm.4199. Epub 2016 Oct 10.
Nat Med. 2016.
PMID: 27723722
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Factors other than hTau overexpression that contribute to tauopathy-like phenotype in rTg4510 mice.
Gamache J, Benzow K, Forster C, Kemper L, Hlynialuk C, Furrow E, Ashe KH, Koob MD.
Gamache J, et al.
Nat Commun. 2019 Jun 6;10(1):2479. doi: 10.1038/s41467-019-10428-1.
Nat Commun. 2019.
PMID: 31171783
Free PMC article.
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Developmental Pathogenicity of 4-Repeat Human Tau Is Lost with the P301L Mutation in Genetically Matched Tau-Transgenic Mice.
Gamache JE, Kemper L, Steuer E, Leinonen-Wright K, Choquette JM, Hlynialuk C, Benzow K, Vossel KA, Xia W, Koob MD, Ashe KH.
Gamache JE, et al.
J Neurosci. 2020 Jan 2;40(1):220-236. doi: 10.1523/JNEUROSCI.1256-19.2019. Epub 2019 Nov 4.
J Neurosci. 2020.
PMID: 31685653
Free PMC article.
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Caspase-2 Inhibitor Blocks Tau Truncation and Restores Excitatory Neurotransmission in Neurons Modeling FTDP-17 Tauopathy.
Singh G, Liu P, Yao KR, Strasser JM, Hlynialuk C, Leinonen-Wright K, Teravskis PJ, Choquette JM, Ikramuddin J, Bresinsky M, Nelson KM, Liao D, Ashe KH, Walters MA, Pockes S.
Singh G, et al.
ACS Chem Neurosci. 2022 May 18;13(10):1549-1557. doi: 10.1021/acschemneuro.2c00100. Epub 2022 May 6.
ACS Chem Neurosci. 2022.
PMID: 35522720
Free PMC article.
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Caspase-2 mRNA levels are not elevated in mild cognitive impairment, Alzheimer's disease, Huntington's disease, or Lewy Body dementia.
Hlynialuk C, Kemper L, Leinonen-Wright K, Petersen RC, Ashe K, Smith B.
Hlynialuk C, et al.
PLoS One. 2022 Sep 21;17(9):e0274784. doi: 10.1371/journal.pone.0274784. eCollection 2022.
PLoS One. 2022.
PMID: 36129947
Free PMC article.
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Aβ∗56 is a stable oligomer that impairs memory function in mice.
Liu P, Lapcinski IP, Hlynialuk CJW, Steuer EL, Loude TJ Jr, Shapiro SL, Kemper LJ, Ashe KH.
Liu P, et al. Among authors: hlynialuk cjw.
iScience. 2024 Feb 15;27(3):109239. doi: 10.1016/j.isci.2024.109239. eCollection 2024 Mar 15.
iScience. 2024.
PMID: 38433923
Free PMC article.
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Mouse endogenous retroviruses can trigger premature transcriptional termination at a distance.
Li J, Akagi K, Hu Y, Trivett AL, Hlynialuk CJ, Swing DA, Volfovsky N, Morgan TC, Golubeva Y, Stephens RM, Smith DE, Symer DE.
Li J, et al.
Genome Res. 2012 May;22(5):870-84. doi: 10.1101/gr.130740.111. Epub 2012 Feb 23.
Genome Res. 2012.
PMID: 22367191
Free PMC article.
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