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An inhibitor of oxidative phosphorylation exploits cancer vulnerability.
Molina JR, Sun Y, Protopopova M, Gera S, Bandi M, Bristow C, McAfoos T, Morlacchi P, Ackroyd J, Agip AA, Al-Atrash G, Asara J, Bardenhagen J, Carrillo CC, Carroll C, Chang E, Ciurea S, Cross JB, Czako B, Deem A, Daver N, de Groot JF, Dong JW, Feng N, Gao G, Gay J, Do MG, Greer J, Giuliani V, Han J, Han L, Henry VK, Hirst J, Huang S, Jiang Y, Kang Z, Khor T, Konoplev S, Lin YH, Liu G, Lodi A, Lofton T, Ma H, Mahendra M, Matre P, Mullinax R, Peoples M, Petrocchi A, Rodriguez-Canale J, Serreli R, Shi T, Smith M, Tabe Y, Theroff J, Tiziani S, Xu Q, Zhang Q, Muller F, DePinho RA, Toniatti C, Draetta GF, Heffernan TP, Konopleva M, Jones P, Di Francesco ME, Marszalek JR. Molina JR, et al. Among authors: hirst j. Nat Med. 2018 Jul;24(7):1036-1046. doi: 10.1038/s41591-018-0052-4. Epub 2018 Jun 11. Nat Med. 2018. PMID: 29892070
Architecture of mammalian respiratory complex I.
Vinothkumar KR, Zhu J, Hirst J. Vinothkumar KR, et al. Among authors: hirst j. Nature. 2014 Nov 6;515(7525):80-84. doi: 10.1038/nature13686. Epub 2014 Sep 7. Nature. 2014. PMID: 25209663 Free PMC article.
Mammalian Respiratory Complex I Through the Lens of Cryo-EM.
Agip AA, Blaza JN, Fedor JG, Hirst J. Agip AA, et al. Among authors: hirst j. Annu Rev Biophys. 2019 May 6;48:165-184. doi: 10.1146/annurev-biophys-052118-115704. Epub 2019 Feb 20. Annu Rev Biophys. 2019. PMID: 30786232 Review.
Structure of inhibitor-bound mammalian complex I.
Bridges HR, Fedor JG, Blaza JN, Di Luca A, Jussupow A, Jarman OD, Wright JJ, Agip AA, Gamiz-Hernandez AP, Roessler MM, Kaila VRI, Hirst J. Bridges HR, et al. Among authors: hirst j. Nat Commun. 2020 Oct 16;11(1):5261. doi: 10.1038/s41467-020-18950-3. Nat Commun. 2020. PMID: 33067417 Free PMC article.
711 results