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Tumor-induced double positive T cells display distinct lineage commitment mechanisms and functions.
J Exp Med. 2022 Jun 6;219(6):e20212169. doi: 10.1084/jem.20212169. Epub 2022 May 23.
J Exp Med. 2022.
PMID: 35604411
Free PMC article.
In situ vaccination with defined factors overcomes T cell exhaustion in distant tumors.
Khalil DN, Suek N, Campesato LF, Budhu S, Redmond D, Samstein RM, Krishna C, Panageas KS, Capanu M, Houghton S, Hirschhorn D, Zappasodi R, Giese R, Gasmi B, Schneider M, Gupta A, Harding JJ, Moral JA, Balachandran VP, Wolchok JD, Merghoub T.
Khalil DN, et al. Among authors: hirschhorn d.
J Clin Invest. 2019 Jul 22;129(8):3435-3447. doi: 10.1172/JCI128562. eCollection 2019 Jul 22.
J Clin Invest. 2019.
PMID: 31329159
Free PMC article.
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Targeting Phosphatidylserine Enhances the Anti-tumor Response to Tumor-Directed Radiation Therapy in a Preclinical Model of Melanoma.
Budhu S, Giese R, Gupta A, Fitzgerald K, Zappasodi R, Schad S, Hirschhorn D, Campesato LF, De Henau O, Gigoux M, Liu C, Mazo G, Deng L, Barker CA, Wolchok JD, Merghoub T.
Budhu S, et al. Among authors: hirschhorn d.
Cell Rep. 2021 Jan 12;34(2):108620. doi: 10.1016/j.celrep.2020.108620.
Cell Rep. 2021.
PMID: 33440157
Free PMC article.
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Cyclophosphamide enhances the antitumor potency of GITR engagement by increasing oligoclonal cytotoxic T cell fitness.
Hirschhorn D, Betof Warner A, Maniyar R, Chow A, Mangarin LM, Cohen AD, Hamadene L, Rizzuto GA, Budhu S, Suek N, Liu C, Houghton AN, Merghoub T, Wolchok JD.
Hirschhorn D, et al.
JCI Insight. 2021 Oct 22;6(20):e151035. doi: 10.1172/jci.insight.151035.
JCI Insight. 2021.
PMID: 34676831
Free PMC article.
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Having the cake and eating it? Clofazimine boosts immunotherapy while limiting side effects.
Kraehenbuehl L, Wolchok JD, Merghoub T, Hirschhorn D.
Kraehenbuehl L, et al. Among authors: hirschhorn d.
Cancer Cell. 2024 Mar 25:S1535-6108(24)00092-8. doi: 10.1016/j.ccell.2024.03.007. Online ahead of print.
Cancer Cell. 2024.
PMID: 38579723
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T cell immunotherapies engage neutrophils to eliminate tumor antigen escape variants.
Hirschhorn D, Budhu S, Kraehenbuehl L, Gigoux M, Schröder D, Chow A, Ricca JM, Gasmi B, De Henau O, Mangarin LMB, Li Y, Hamadene L, Flamar AL, Choi H, Cortez CA, Liu C, Holland A, Schad S, Schulze I, Betof Warner A, Hollmann TJ, Arora A, Panageas KS, Rizzuto GA, Duhen R, Weinberg AD, Spencer CN, Ng D, He XY, Albrengues J, Redmond D, Egeblad M, Wolchok JD, Merghoub T.
Hirschhorn D, et al.
Cell. 2023 Mar 30;186(7):1432-1447.e17. doi: 10.1016/j.cell.2023.03.007.
Cell. 2023.
PMID: 37001503
Free PMC article.
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The ectonucleotidase CD39 identifies tumor-reactive CD8+ T cells predictive of immune checkpoint blockade efficacy in human lung cancer.
Chow A, Uddin FZ, Liu M, Dobrin A, Nabet BY, Mangarin L, Lavin Y, Rizvi H, Tischfield SE, Quintanal-Villalonga A, Chan JM, Shah N, Allaj V, Manoj P, Mattar M, Meneses M, Landau R, Ward M, Kulick A, Kwong C, Wierzbicki M, Yavner J, Egger J, Chavan SS, Farillas A, Holland A, Sridhar H, Ciampricotti M, Hirschhorn D, Guan X, Richards AL, Heller G, Mansilla-Soto J, Sadelain M, Klebanoff CA, Hellmann MD, Sen T, de Stanchina E, Wolchok JD, Merghoub T, Rudin CM.
Chow A, et al. Among authors: hirschhorn d.
Immunity. 2023 Jan 10;56(1):93-106.e6. doi: 10.1016/j.immuni.2022.12.001. Epub 2022 Dec 26.
Immunity. 2023.
PMID: 36574773
Free PMC article.
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