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PI(3,4)P2 Signaling in Cancer and Metabolism.
Gozzelino L, De Santis MC, Gulluni F, Hirsch E, Martini M. Gozzelino L, et al. Among authors: hirsch e. Front Oncol. 2020 Mar 31;10:360. doi: 10.3389/fonc.2020.00360. eCollection 2020. Front Oncol. 2020. PMID: 32296634 Free PMC article. Review.
PI3K keeps the balance between metabolism and cancer.
Braccini L, Ciraolo E, Martini M, Pirali T, Germena G, Rolfo K, Hirsch E. Braccini L, et al. Among authors: hirsch e. Adv Biol Regul. 2012 Sep;52(3):389-405. doi: 10.1016/j.jbior.2012.04.002. Epub 2012 Apr 24. Adv Biol Regul. 2012. PMID: 22884032 Review.
Targeting PI3K in Cancer: Any Good News?
Martini M, Ciraolo E, Gulluni F, Hirsch E. Martini M, et al. Among authors: hirsch e. Front Oncol. 2013 May 8;3:108. doi: 10.3389/fonc.2013.00108. eCollection 2013. Front Oncol. 2013. PMID: 23658859 Free PMC article.
Spatiotemporal control of endocytosis by phosphatidylinositol-3,4-bisphosphate.
Posor Y, Eichhorn-Gruenig M, Puchkov D, Schöneberg J, Ullrich A, Lampe A, Müller R, Zarbakhsh S, Gulluni F, Hirsch E, Krauss M, Schultz C, Schmoranzer J, Noé F, Haucke V. Posor Y, et al. Among authors: hirsch e. Nature. 2013 Jul 11;499(7457):233-7. doi: 10.1038/nature12360. Epub 2013 Jul 3. Nature. 2013. PMID: 23823722
PI3K class II α controls spatially restricted endosomal PtdIns3P and Rab11 activation to promote primary cilium function.
Franco I, Gulluni F, Campa CC, Costa C, Margaria JP, Ciraolo E, Martini M, Monteyne D, De Luca E, Germena G, Posor Y, Maffucci T, Marengo S, Haucke V, Falasca M, Perez-Morga D, Boletta A, Merlo GR, Hirsch E. Franco I, et al. Among authors: hirsch e. Dev Cell. 2014 Mar 31;28(6):647-58. doi: 10.1016/j.devcel.2014.01.022. Dev Cell. 2014. PMID: 24697898 Free PMC article.
PI3K/AKT signaling pathway and cancer: an updated review.
Martini M, De Santis MC, Braccini L, Gulluni F, Hirsch E. Martini M, et al. Among authors: hirsch e. Ann Med. 2014 Sep;46(6):372-83. doi: 10.3109/07853890.2014.912836. Epub 2014 Jun 5. Ann Med. 2014. PMID: 24897931 Review.
Methods to measure the enzymatic activity of PI3Ks.
Ciraolo E, Gulluni F, Hirsch E. Ciraolo E, et al. Among authors: hirsch e. Methods Enzymol. 2014;543:115-40. doi: 10.1016/B978-0-12-801329-8.00006-4. Methods Enzymol. 2014. PMID: 24924130
Measurement of PIP3 levels reveals an unexpected role for p110β in early adaptive responses to p110α-specific inhibitors in luminal breast cancer.
Costa C, Ebi H, Martini M, Beausoleil SA, Faber AC, Jakubik CT, Huang A, Wang Y, Nishtala M, Hall B, Rikova K, Zhao J, Hirsch E, Benes CH, Engelman JA. Costa C, et al. Among authors: hirsch e. Cancer Cell. 2015 Jan 12;27(1):97-108. doi: 10.1016/j.ccell.2014.11.007. Epub 2014 Dec 24. Cancer Cell. 2015. PMID: 25544637 Free PMC article.
In Vivo Role of INPP4B in Tumor and Metastasis Suppression through Regulation of PI3K-AKT Signaling at Endosomes.
Li Chew C, Lunardi A, Gulluni F, Ruan DT, Chen M, Salmena L, Nishino M, Papa A, Ng C, Fung J, Clohessy JG, Sasaki J, Sasaki T, Bronson RT, Hirsch E, Pandolfi PP. Li Chew C, et al. Among authors: hirsch e. Cancer Discov. 2015 Jul;5(7):740-51. doi: 10.1158/2159-8290.CD-14-1347. Epub 2015 Apr 16. Cancer Discov. 2015. PMID: 25883022 Free PMC article.
1,540 results