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New pre-clinical evidence of anti-inflammatory effect and safety of a substituted fluorophenyl imidazole.
Dos Santos Nascimento MVP, Mattar Munhoz AC, De Campos Facchin BM, Fratoni E, Rossa TA, Mandolesi Sá M, Campa CC, Ciraolo E, Hirsch E, Dalmarco EM. Dos Santos Nascimento MVP, et al. Among authors: hirsch e. Biomed Pharmacother. 2019 Mar;111:1399-1407. doi: 10.1016/j.biopha.2019.01.052. Epub 2019 Jan 19. Biomed Pharmacother. 2019. PMID: 30841455 Free article.
Inhalation of the prodrug PI3K inhibitor CL27c improves lung function in asthma and fibrosis.
Campa CC, Silva RL, Margaria JP, Pirali T, Mattos MS, Kraemer LR, Reis DC, Grosa G, Copperi F, Dalmarco EM, Lima-Júnior RCP, Aprile S, Sala V, Dal Bello F, Prado DS, Alves-Filho JC, Medana C, Cassali GD, Tron GC, Teixeira MM, Ciraolo E, Russo RC, Hirsch E. Campa CC, et al. Among authors: hirsch e. Nat Commun. 2018 Dec 12;9(1):5232. doi: 10.1038/s41467-018-07698-6. Nat Commun. 2018. PMID: 30542075 Free PMC article.
Methods to measure the enzymatic activity of PI3Ks.
Ciraolo E, Gulluni F, Hirsch E. Ciraolo E, et al. Among authors: hirsch e. Methods Enzymol. 2014;543:115-40. doi: 10.1016/B978-0-12-801329-8.00006-4. Methods Enzymol. 2014. PMID: 24924130
Crossroads of PI3K and Rac pathways.
Campa CC, Ciraolo E, Ghigo A, Germena G, Hirsch E. Campa CC, et al. Among authors: hirsch e. Small GTPases. 2015;6(2):71-80. doi: 10.4161/21541248.2014.989789. Epub 2015 May 5. Small GTPases. 2015. PMID: 25942647 Free PMC article. Review.
Measuring PI3K lipid kinase activity.
Ciraolo E, Perino A, Hirsch E. Ciraolo E, et al. Among authors: hirsch e. Methods Mol Biol. 2012;795:55-67. doi: 10.1007/978-1-61779-337-0_4. Methods Mol Biol. 2012. PMID: 21960215
Genetic Deletion and Pharmacological Inhibition of PI3K γ Reduces Neutrophilic Airway Inflammation and Lung Damage in Mice with Cystic Fibrosis-Like Lung Disease.
Galluzzo M, Ciraolo E, Lucattelli M, Hoxha E, Ulrich M, Campa CC, Lungarella G, Doring G, Zhou-Suckow Z, Mall M, Hirsch E, De Rose V. Galluzzo M, et al. Among authors: hirsch e. Mediators Inflamm. 2015;2015:545417. doi: 10.1155/2015/545417. Epub 2015 Jun 21. Mediators Inflamm. 2015. PMID: 26185363 Free PMC article.
1,540 results