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Single Cell Genetic Profiling of Tumors of Breast Cancer Patients Aged 50 Years and Older Reveals Enormous Intratumor Heterogeneity Independent of Individual Prognosis.
Liegmann AS, Heselmeyer-Haddad K, Lischka A, Hirsch D, Chen WD, Torres I, Gemoll T, Rody A, Thorns C, Gertz EM, Alkemade H, Hu Y, Habermann JK, Ried T. Liegmann AS, et al. Among authors: hirsch d. Cancers (Basel). 2021 Jul 5;13(13):3366. doi: 10.3390/cancers13133366. Cancers (Basel). 2021. PMID: 34282768 Free PMC article.
LGR5 positivity defines stem-like cells in colorectal cancer.
Hirsch D, Barker N, McNeil N, Hu Y, Camps J, McKinnon K, Clevers H, Ried T, Gaiser T. Hirsch D, et al. Carcinogenesis. 2014 Apr;35(4):849-58. doi: 10.1093/carcin/bgt377. Epub 2013 Nov 26. Carcinogenesis. 2014. PMID: 24282287 Free PMC article.
The evolution of single cell-derived colorectal cancer cell lines is dominated by the continued selection of tumor-specific genomic imbalances, despite random chromosomal instability.
Wangsa D, Braun R, Schiefer M, Gertz EM, Bronder D, Quintanilla I, Padilla-Nash HM, Torres I, Hunn C, Warner L, Buishand FO, Hu Y, Hirsch D, Gaiser T, Camps J, Schwartz R, Schäffer AA, Heselmeyer-Haddad K, Ried T. Wangsa D, et al. Among authors: hirsch d. Carcinogenesis. 2018 Jul 30;39(8):993-1005. doi: 10.1093/carcin/bgy068. Carcinogenesis. 2018. PMID: 29800151 Free PMC article.
Hard wiring of normal tissue-specific chromosome-wide gene expression levels is an additional factor driving cancer type-specific aneuploidies.
Patkar S, Heselmeyer-Haddad K, Auslander N, Hirsch D, Camps J, Bronder D, Brown M, Chen WD, Lokanga R, Wangsa D, Wangsa D, Hu Y, Lischka A, Braun R, Emons G, Ghadimi BM, Gaedcke J, Grade M, Montagna C, Lazebnik Y, Difilippantonio MJ, Habermann JK, Auer G, Ruppin E, Ried T. Patkar S, et al. Among authors: hirsch d. Genome Med. 2021 May 25;13(1):93. doi: 10.1186/s13073-021-00905-y. Genome Med. 2021. PMID: 34034815 Free PMC article.
519 results