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Synthesis of novel vitamin K derivatives with alkylated phenyl groups introduced at the ω-terminal side chain and evaluation of their neural differentiation activities.
Sakane R, Kimura K, Hirota Y, Ishizawa M, Takagi Y, Wada A, Kuwahara S, Makishima M, Suhara Y. Sakane R, et al. Among authors: hirota y. Bioorg Med Chem Lett. 2017 Nov 1;27(21):4881-4884. doi: 10.1016/j.bmcl.2017.09.038. Epub 2017 Sep 18. Bioorg Med Chem Lett. 2017. PMID: 28947152 Free article.
Study on structure-activity relationship of vitamin K derivatives: Conversion of the naphthoquinone part into another aromatic ring and evaluation of their neuronal differentiation-inducing activity.
Yoshimura H, Hirota Y, Soda S, Okazeri M, Takagi Y, Takeuchi A, Tode C, Kamao M, Osakabe N, Suhara Y. Yoshimura H, et al. Among authors: hirota y. Bioorg Med Chem Lett. 2020 Apr 15;30(8):127059. doi: 10.1016/j.bmcl.2020.127059. Epub 2020 Feb 24. Bioorg Med Chem Lett. 2020. PMID: 32127260 Free article.
Exploring Novel Vitamin K Derivatives with Anti-SARS-CoV-2 Activity.
Homma T, Okamoto M, Koharazawa R, Hayakawa M, Fushimi T, Tode C, Hirota Y, Osakabe N, Baba M, Suhara Y. Homma T, et al. Among authors: hirota y. ACS Omega. 2023 Nov 1;8(45):42248-42263. doi: 10.1021/acsomega.3c04175. eCollection 2023 Nov 14. ACS Omega. 2023. PMID: 38024673 Free PMC article.
Vitamin K2 biosynthetic enzyme, UBIAD1 is essential for embryonic development of mice.
Nakagawa K, Sawada N, Hirota Y, Uchino Y, Suhara Y, Hasegawa T, Amizuka N, Okamoto T, Tsugawa N, Kamao M, Funahashi N, Okano T. Nakagawa K, et al. Among authors: hirota y. PLoS One. 2014 Aug 15;9(8):e104078. doi: 10.1371/journal.pone.0104078. eCollection 2014. PLoS One. 2014. PMID: 25127365 Free PMC article.
1,541 results