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FXYD3 functionally demarcates an ancestral breast cancer stem cell subpopulation with features of drug-tolerant persisters.
Li M, Nishimura T, Takeuchi Y, Hongu T, Wang Y, Shiokawa D, Wang K, Hirose H, Sasahara A, Yano M, Ishikawa S, Inokuchi M, Ota T, Tanabe M, Tada KI, Akiyama T, Cheng X, Liu CC, Yamashita T, Sugano S, Uchida Y, Chiba T, Asahara H, Nakagawa M, Sato S, Miyagi Y, Shimamura T, Nagai LAE, Kanai A, Katoh M, Nomura S, Nakato R, Suzuki Y, Tojo A, Voon DC, Ogawa S, Okamoto K, Foukakis T, Gotoh N. Li M, et al. Among authors: hirose h. J Clin Invest. 2023 Nov 15;133(22):e166666. doi: 10.1172/JCI166666. J Clin Invest. 2023. PMID: 37966117 Free PMC article.
Single-cell colocalization analysis using a deep generative model.
Kojima Y, Mii S, Hayashi S, Hirose H, Ishikawa M, Akiyama M, Enomoto A, Shimamura T. Kojima Y, et al. Among authors: hirose h. Cell Syst. 2024 Feb 21;15(2):180-192.e7. doi: 10.1016/j.cels.2024.01.007. Cell Syst. 2024. PMID: 38387441
Acidic extracellular pH drives accumulation of N1-acetylspermidine and recruitment of protumor neutrophils.
Kato M, Maeda K, Nakahara R, Hirose H, Kondo A, Aki S, Sugaya M, Hibino S, Nishida M, Hasegawa M, Morita H, Ando R, Tsuchida R, Yoshida M, Kodama T, Yanai H, Shimamura T, Osawa T. Kato M, et al. Among authors: hirose h. PNAS Nexus. 2023 Oct 10;2(10):pgad306. doi: 10.1093/pnasnexus/pgad306. eCollection 2023 Oct. PNAS Nexus. 2023. PMID: 37822765 Free PMC article.
Hypoxia activates SREBP2 through Golgi disassembly in bone marrow-derived monocytes for enhanced tumor growth.
Nakahara R, Aki S, Sugaya M, Hirose H, Kato M, Maeda K, Sakamoto DM, Kojima Y, Nishida M, Ando R, Muramatsu M, Pan M, Tsuchida R, Matsumura Y, Yanai H, Takano H, Yao R, Sando S, Shibuya M, Sakai J, Kodama T, Kidoya H, Shimamura T, Osawa T. Nakahara R, et al. Among authors: hirose h. EMBO J. 2023 Nov 15;42(22):e114032. doi: 10.15252/embj.2023114032. Epub 2023 Oct 2. EMBO J. 2023. PMID: 37781951 Free PMC article.
Spatial and single-cell colocalisation analysis reveals MDK-mediated immunosuppressive environment with regulatory T cells in colorectal carcinogenesis.
Hashimoto M, Kojima Y, Sakamoto T, Ozato Y, Nakano Y, Abe T, Hosoda K, Saito H, Higuchi S, Hisamatsu Y, Toshima T, Yonemura Y, Masuda T, Hata T, Nagayama S, Kagawa K, Goto Y, Utou M, Gamachi A, Imamura K, Kuze Y, Zenkoh J, Suzuki A, Takahashi K, Niida A, Hirose H, Hayashi S, Koseki J, Fukuchi S, Murakami K, Yoshizumi T, Kadomatsu K, Tobo T, Oda Y, Uemura M, Eguchi H, Doki Y, Mori M, Oshima M, Shibata T, Suzuki Y, Shimamura T, Mimori K. Hashimoto M, et al. Among authors: hirose h. EBioMedicine. 2024 Apr 9:105102. doi: 10.1016/j.ebiom.2024.105102. Online ahead of print. EBioMedicine. 2024. PMID: 38614865 Free article.
1,335 results