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Inhibition of cellular RNA methyltransferase abrogates influenza virus capping and replication.
Tsukamoto Y, Hiono T, Yamada S, Matsuno K, Faist A, Claff T, Hou J, Namasivayam V, Vom Hemdt A, Sugimoto S, Ng JY, Christensen MH, Tesfamariam YM, Wolter S, Juranek S, Zillinger T, Bauer S, Hirokawa T, Schmidt FI, Kochs G, Shimojima M, Huang YS, Pichlmair A, Kümmerer BM, Sakoda Y, Schlee M, Brunotte L, Müller CE, Igarashi M, Kato H. Tsukamoto Y, et al. Among authors: hirokawa t. Science. 2023 Feb 10;379(6632):586-591. doi: 10.1126/science.add0875. Epub 2023 Feb 9. Science. 2023. PMID: 36758070
Attenuation of SARS-CoV-2 replication and associated inflammation by concomitant targeting of viral and host cap 2'-O-ribose methyltransferases.
Bergant V, Yamada S, Grass V, Tsukamoto Y, Lavacca T, Krey K, Mühlhofer MT, Wittmann S, Ensser A, Herrmann A, Vom Hemdt A, Tomita Y, Matsuyama S, Hirokawa T, Huang Y, Piras A, Jakwerth CA, Oelsner M, Thieme S, Graf A, Krebs S, Blum H, Kümmerer BM, Stukalov A, Schmidt-Weber CB, Igarashi M, Gramberg T, Pichlmair A, Kato H. Bergant V, et al. Among authors: hirokawa t. EMBO J. 2022 Sep 1;41(17):e111608. doi: 10.15252/embj.2022111608. Epub 2022 Jul 25. EMBO J. 2022. PMID: 35833542 Free PMC article.
Design and synthesis of cyclic ADP-4-thioribose as a stable equivalent of cyclic ADP-ribose, a calcium ion-mobilizing second messenger.
Tsuzuki T, Sakaguchi N, Kudoh T, Takano S, Uehara M, Murayama T, Sakurai T, Hashii M, Higashida H, Weber K, Guse AH, Kameda T, Hirokawa T, Kumaki Y, Potter BV, Fukuda H, Arisawa M, Shuto S. Tsuzuki T, et al. Among authors: hirokawa t. Angew Chem Int Ed Engl. 2013 Jun 24;52(26):6633-7. doi: 10.1002/anie.201302098. Epub 2013 May 13. Angew Chem Int Ed Engl. 2013. PMID: 23670921 Free PMC article. No abstract available.
Potential anti-COVID-19 agents, cepharanthine and nelfinavir, and their usage for combination treatment.
Ohashi H, Watashi K, Saso W, Shionoya K, Iwanami S, Hirokawa T, Shirai T, Kanaya S, Ito Y, Kim KS, Nomura T, Suzuki T, Nishioka K, Ando S, Ejima K, Koizumi Y, Tanaka T, Aoki S, Kuramochi K, Suzuki T, Hashiguchi T, Maenaka K, Matano T, Muramatsu M, Saijo M, Aihara K, Iwami S, Takeda M, McKeating JA, Wakita T. Ohashi H, et al. Among authors: hirokawa t. iScience. 2021 Apr 23;24(4):102367. doi: 10.1016/j.isci.2021.102367. Epub 2021 Mar 26. iScience. 2021. PMID: 33817567 Free PMC article.
299 results