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Page 1
Inhibiting SCAP/SREBP exacerbates liver injury and carcinogenesis in murine nonalcoholic steatohepatitis.
Kawamura S, Matsushita Y, Kurosaki S, Tange M, Fujiwara N, Hayata Y, Hayakawa Y, Suzuki N, Hata M, Tsuboi M, Kishikawa T, Kinoshita H, Nakatsuka T, Sato M, Kudo Y, Hoshida Y, Umemura A, Eguchi A, Ikenoue T, Hirata Y, Uesugi M, Tateishi R, Tateishi K, Fujishiro M, Koike K, Nakagawa H. Kawamura S, et al. Among authors: hirata y. J Clin Invest. 2022 Jun 1;132(11):e151895. doi: 10.1172/JCI151895. J Clin Invest. 2022. PMID: 35380992 Free PMC article.
CPT2 downregulation adapts HCC to lipid-rich environment and promotes carcinogenesis via acylcarnitine accumulation in obesity.
Fujiwara N, Nakagawa H, Enooku K, Kudo Y, Hayata Y, Nakatsuka T, Tanaka Y, Tateishi R, Hikiba Y, Misumi K, Tanaka M, Hayashi A, Shibahara J, Fukayama M, Arita J, Hasegawa K, Hirschfield H, Hoshida Y, Hirata Y, Otsuka M, Tateishi K, Koike K. Fujiwara N, et al. Among authors: hirata y. Gut. 2018 Aug;67(8):1493-1504. doi: 10.1136/gutjnl-2017-315193. Epub 2018 Feb 6. Gut. 2018. PMID: 29437870 Free PMC article.
Cell fate analysis of zone 3 hepatocytes in liver injury and tumorigenesis.
Kurosaki S, Nakagawa H, Hayata Y, Kawamura S, Matsushita Y, Yamada T, Uchino K, Hayakawa Y, Suzuki N, Hata M, Tsuboi M, Kinoshita H, Tanaka Y, Nakatsuka T, Hirata Y, Tateishi K, Koike K. Kurosaki S, et al. Among authors: hirata y. JHEP Rep. 2021 May 27;3(4):100315. doi: 10.1016/j.jhepr.2021.100315. eCollection 2021 Aug. JHEP Rep. 2021. PMID: 34345813 Free PMC article.
Altered composition of fatty acids exacerbates hepatotumorigenesis during activation of the phosphatidylinositol 3-kinase pathway.
Kudo Y, Tanaka Y, Tateishi K, Yamamoto K, Yamamoto S, Mohri D, Isomura Y, Seto M, Nakagawa H, Asaoka Y, Tada M, Ohta M, Ijichi H, Hirata Y, Otsuka M, Ikenoue T, Maeda S, Shiina S, Yoshida H, Nakajima O, Kanai F, Omata M, Koike K. Kudo Y, et al. Among authors: hirata y. J Hepatol. 2011 Dec;55(6):1400-8. doi: 10.1016/j.jhep.2011.03.025. Epub 2011 May 19. J Hepatol. 2011. PMID: 21703185
Loss of liver E-cadherin induces sclerosing cholangitis and promotes carcinogenesis.
Nakagawa H, Hikiba Y, Hirata Y, Font-Burgada J, Sakamoto K, Hayakawa Y, Taniguchi K, Umemura A, Kinoshita H, Sakitani K, Nishikawa Y, Hirano K, Ikenoue T, Ijichi H, Dhar D, Shibata W, Akanuma M, Koike K, Karin M, Maeda S. Nakagawa H, et al. Among authors: hirata y. Proc Natl Acad Sci U S A. 2014 Jan 21;111(3):1090-5. doi: 10.1073/pnas.1322731111. Epub 2014 Jan 6. Proc Natl Acad Sci U S A. 2014. PMID: 24395807 Free PMC article.
Mature gastric chief cells are not required for the development of metaplasia.
Kinoshita H, Hayakawa Y, Niu Z, Konishi M, Hata M, Tsuboi M, Hayata Y, Hikiba Y, Ihara S, Nakagawa H, Hirata Y, Wang TC, Koike K. Kinoshita H, et al. Among authors: hirata y. Am J Physiol Gastrointest Liver Physiol. 2018 May 1;314(5):G583-G596. doi: 10.1152/ajpgi.00351.2017. Epub 2018 Jan 18. Am J Physiol Gastrointest Liver Physiol. 2018. PMID: 29345968 Free PMC article.
GPR30-Expressing Gastric Chief Cells Do Not Dedifferentiate But Are Eliminated via PDK-Dependent Cell Competition During Development of Metaplasia.
Hata M, Kinoshita H, Hayakawa Y, Konishi M, Tsuboi M, Oya Y, Kurokawa K, Hayata Y, Nakagawa H, Tateishi K, Fujiwara H, Hirata Y, Worthley DL, Muranishi Y, Furukawa T, Kon S, Tomita H, Wang TC, Koike K. Hata M, et al. Among authors: hirata y. Gastroenterology. 2020 May;158(6):1650-1666.e15. doi: 10.1053/j.gastro.2020.01.046. Epub 2020 Feb 4. Gastroenterology. 2020. PMID: 32032583 Free PMC article.
Deletion of Histone Methyltransferase G9a Suppresses Mutant Kras-driven Pancreatic Carcinogenesis.
Kato H, Tateishi K, Fujiwara H, Ijichi H, Yamamoto K, Nakatsuka T, Kakiuchi M, Sano M, Kudo Y, Hayakawa Y, Nakagawa H, Tanaka Y, Otsuka M, Hirata Y, Tachibana M, Shinkai Y, Koike K. Kato H, et al. Among authors: hirata y. Cancer Genomics Proteomics. 2020 Nov-Dec;17(6):695-705. doi: 10.21873/cgp.20224. Cancer Genomics Proteomics. 2020. PMID: 33099471 Free PMC article.
Axin2+ Peribiliary Glands in the Periampullary Region Generate Biliary Epithelial Stem Cells That Give Rise to Ampullary Carcinoma.
Hayata Y, Nakagawa H, Kurosaki S, Kawamura S, Matsushita Y, Hayakawa Y, Suzuki N, Hata M, Tsuboi M, Kinoshita H, Miyabayashi K, Mizutani H, Nakagomi R, Ikenoue T, Hirata Y, Arita J, Hasegawa K, Tateishi K, Koike K. Hayata Y, et al. Among authors: hirata y. Gastroenterology. 2021 May;160(6):2133-2148.e6. doi: 10.1053/j.gastro.2021.01.028. Epub 2021 Jan 16. Gastroenterology. 2021. PMID: 33465373 Free article.
3,129 results