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Dietary Omega-3 Fatty Acid Dampens Allergic Rhinitis via Eosinophilic Production of the Anti-Allergic Lipid Mediator 15-Hydroxyeicosapentaenoic Acid in Mice.
Sawane K, Nagatake T, Hosomi K, Hirata SI, Adachi J, Abe Y, Isoyama J, Suzuki H, Matsunaga A, Fukumitsu S, Aida K, Tomonaga T, Arita M, Kunisawa J. Sawane K, et al. Among authors: hirata si. Nutrients. 2019 Nov 22;11(12):2868. doi: 10.3390/nu11122868. Nutrients. 2019. PMID: 31766714 Free PMC article.
Maternal ω3 docosapentaenoic acid inhibits infant allergic dermatitis through TRAIL-expressing plasmacytoid dendritic cells in mice.
Hirata SI, Nagatake T, Sawane K, Hosomi K, Honda T, Ono S, Shibuya N, Saito E, Adachi J, Abe Y, Isoyama J, Suzuki H, Matsunaga A, Tomonaga T, Kiyono H, Kabashima K, Arita M, Kunisawa J. Hirata SI, et al. Allergy. 2020 Aug;75(8):1939-1955. doi: 10.1111/all.14217. Epub 2020 Mar 4. Allergy. 2020. PMID: 32027039 Free PMC article.
ω3 fatty acid metabolite, 12-hydroxyeicosapentaenoic acid, alleviates contact hypersensitivity by downregulation of CXCL1 and CXCL2 gene expression in keratinocytes via retinoid X receptor α.
Saika A, Nagatake T, Hirata SI, Sawane K, Adachi J, Abe Y, Isoyama J, Morimoto S, Node E, Tiwari P, Hosomi K, Matsunaga A, Honda T, Tomonaga T, Arita M, Kabashima K, Kunisawa J. Saika A, et al. Among authors: hirata si. FASEB J. 2021 Apr;35(4):e21354. doi: 10.1096/fj.202001687R. FASEB J. 2021. PMID: 33749892
Gut microbiome, metabolome, and allergic diseases.
Hirata SI, Kunisawa J. Hirata SI, et al. Allergol Int. 2017 Oct;66(4):523-528. doi: 10.1016/j.alit.2017.06.008. Epub 2017 Jul 8. Allergol Int. 2017. PMID: 28693971 Free article. Review.
Development of a bivalent food poisoning vaccine: augmented antigenicity of the C-terminus of Clostridium perfringens enterotoxin by fusion with the B subunit of Escherichia coli Shiga toxin 2.
Hosomi K, Hinenoya A, Suzuki H, Nagatake T, Nishino T, Tojima Y, Hirata SI, Matsunaga A, Kondoh M, Yamasaki S, Kunisawa J. Hosomi K, et al. Among authors: hirata si. Int Immunol. 2019 Feb 15;31(2):91-100. doi: 10.1093/intimm/dxy071. Int Immunol. 2019. PMID: 30329068
Intestinal microbe-dependent ω3 lipid metabolite αKetoA prevents inflammatory diseases in mice and cynomolgus macaques.
Nagatake T, Kishino S, Urano E, Murakami H, Kitamura N, Konishi K, Ohno H, Tiwari P, Morimoto S, Node E, Adachi J, Abe Y, Isoyama J, Sawane K, Honda T, Inoue A, Uwamizu A, Matsuzaka T, Miyamoto Y, Hirata SI, Saika A, Shibata Y, Hosomi K, Matsunaga A, Shimano H, Arita M, Aoki J, Oka M, Matsutani A, Tomonaga T, Kabashima K, Miyachi M, Yasutomi Y, Ogawa J, Kunisawa J. Nagatake T, et al. Among authors: hirata si. Mucosal Immunol. 2022 Feb;15(2):289-300. doi: 10.1038/s41385-021-00477-5. Epub 2022 Jan 10. Mucosal Immunol. 2022. PMID: 35013573 Free PMC article.
BLT1 mediates commensal bacteria-dependent innate immune signals to enhance antigen-specific intestinal IgA responses.
Nagatake T, Hirata SI, Koga T, Kuroda E, Kobari S, Suzuki H, Hosomi K, Matsumoto N, Yanrismet Y, Shimojou M, Morimoto S, Sasaki F, Ishii KJ, Yokomizo T, Kunisawa J. Nagatake T, et al. Among authors: hirata si. Mucosal Immunol. 2019 Sep;12(5):1082-1091. doi: 10.1038/s41385-019-0175-z. Epub 2019 May 29. Mucosal Immunol. 2019. PMID: 31142830 Free article.
43 results