Hirano S - Search Results

1

Engineered CRISPR-Cas9 nuclease with expanded targeting space.

Nishimasu H, Shi X, Ishiguro S, Gao L, Hirano S, Okazaki S, Noda T, Abudayyeh OO, Gootenberg JS, Mori H, Oura S, Holmes B, Tanaka M, Seki M, Hirano H, Aburatani H, Ishitani R, Ikawa M, Yachie N, Zhang F, Nureki O. Nishimasu H, et al. Among authors: hirano h, hirano s. Science. 2018 Sep 21;361(6408):1259-1262. doi: 10.1126/science.aas9129. Epub 2018 Aug 30. Science. 2018. PMID: 30166441 Free PMC article.

2

Structural Basis for the Catalytic Mechanism of DncV, Bacterial Homolog of Cyclic GMP-AMP Synthase.

Kato K, Ishii R, Hirano S, Ishitani R, Nureki O. Kato K, et al. Among authors: hirano s. Structure. 2015 May 5;23(5):843-850. doi: 10.1016/j.str.2015.01.023. Epub 2015 Apr 9. Structure. 2015. PMID: 25865248 Free article.

3

Structural Basis for the Altered PAM Specificities of Engineered CRISPR-Cas9.

Hirano S, Nishimasu H, Ishitani R, Nureki O. Hirano S, et al. Mol Cell. 2016 Mar 17;61(6):886-94. doi: 10.1016/j.molcel.2016.02.018. Mol Cell. 2016. PMID: 26990991 Free article.

4

Applications of the CRISPR-Cas9 system in kidney research.

Higashijima Y, Hirano S, Nangaku M, Nureki O. Higashijima Y, et al. Among authors: hirano s. Kidney Int. 2017 Aug;92(2):324-335. doi: 10.1016/j.kint.2017.01.037. Epub 2017 Apr 20. Kidney Int. 2017. PMID: 28433382 Free article. Review.

5

Real-space and real-time dynamics of CRISPR-Cas9 visualized by high-speed atomic force microscopy.

Shibata M, Nishimasu H, Kodera N, Hirano S, Ando T, Uchihashi T, Nureki O. Shibata M, et al. Among authors: hirano s. Nat Commun. 2017 Nov 10;8(1):1430. doi: 10.1038/s41467-017-01466-8. Nat Commun. 2017. PMID: 29127285 Free PMC article.

6

Structural insights into cGAMP degradation by Ecto-nucleotide pyrophosphatase phosphodiesterase 1.

Kato K, Nishimasu H, Oikawa D, Hirano S, Hirano H, Kasuya G, Ishitani R, Tokunaga F, Nureki O. Kato K, et al. Among authors: hirano h, hirano s. Nat Commun. 2018 Oct 24;9(1):4424. doi: 10.1038/s41467-018-06922-7. Nat Commun. 2018. PMID: 30356045 Free PMC article.

7

Cap-specific terminal N ⁶-methylation of RNA by an RNA polymerase II-associated methyltransferase.

Akichika S, Hirano S, Shichino Y, Suzuki T, Nishimasu H, Ishitani R, Sugita A, Hirose Y, Iwasaki S, Nureki O, Suzuki T. Akichika S, et al. Among authors: hirano s. Science. 2019 Jan 11;363(6423):eaav0080. doi: 10.1126/science.aav0080. Epub 2018 Nov 22. Science. 2019. PMID: 30467178

8

Structural basis for the promiscuous PAM recognition by Corynebacterium diphtheriae Cas9.

Hirano S, Abudayyeh OO, Gootenberg JS, Horii T, Ishitani R, Hatada I, Zhang F, Nishimasu H, Nureki O. Hirano S, et al. Nat Commun. 2019 Apr 29;10(1):1968. doi: 10.1038/s41467-019-09741-6. Nat Commun. 2019. PMID: 31036811 Free PMC article.

9

Crystal structure of Drosophila Piwi.

Yamaguchi S, Oe A, Nishida KM, Yamashita K, Kajiya A, Hirano S, Matsumoto N, Dohmae N, Ishitani R, Saito K, Siomi H, Nishimasu H, Siomi MC, Nureki O. Yamaguchi S, et al. Among authors: hirano s. Nat Commun. 2020 Feb 12;11(1):858. doi: 10.1038/s41467-020-14687-1. Nat Commun. 2020. PMID: 32051406 Free PMC article.

10

Structure of the OMEGA nickase IsrB in complex with ωRNA and target DNA.

Hirano S, Kappel K, Altae-Tran H, Faure G, Wilkinson ME, Kannan S, Demircioglu FE, Yan R, Shiozaki M, Yu Z, Makarova KS, Koonin EV, Macrae RK, Zhang F. Hirano S, et al. Nature. 2022 Oct;610(7932):575-581. doi: 10.1038/s41586-022-05324-6. Epub 2022 Oct 12. Nature. 2022. PMID: 36224386 Free PMC article.

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