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Loss of endothelial CFTR drives barrier failure and edema formation in lung infection and can be targeted by CFTR potentiation.
Erfinanda L, Zou L, Gutbier B, Kneller L, Weidenfeld S, Michalick L, Lei D, Reppe K, Teixeira Alves LG, Schneider B, Zhang Q, Li C, Fatykhova D, Schneider P, Liedtke W, Sohara E, Mitchell TJ, Gruber AD, Hocke A, Hippenstiel S, Suttorp N, Olschewski A, Mall MA, Witzenrath M, Kuebler WM. Erfinanda L, et al. Among authors: hippenstiel s. Sci Transl Med. 2022 Dec 7;14(674):eabg8577. doi: 10.1126/scitranslmed.abg8577. Epub 2022 Dec 7. Sci Transl Med. 2022. PMID: 36475904
Legionella pneumophila glucosyltransferase inhibits host elongation factor 1A.
Belyi Y, Niggeweg R, Opitz B, Vogelsgesang M, Hippenstiel S, Wilm M, Aktories K. Belyi Y, et al. Among authors: hippenstiel s. Proc Natl Acad Sci U S A. 2006 Nov 7;103(45):16953-8. doi: 10.1073/pnas.0601562103. Epub 2006 Oct 26. Proc Natl Acad Sci U S A. 2006. PMID: 17068130 Free PMC article.
Rho protein inactivation induced apoptosis of cultured human endothelial cells.
Hippenstiel S, Schmeck B, N'Guessan PD, Seybold J, Krüll M, Preissner K, Eichel-Streiber CV, Suttorp N. Hippenstiel S, et al. Am J Physiol Lung Cell Mol Physiol. 2002 Oct;283(4):L830-8. doi: 10.1152/ajplung.00467.2001. Am J Physiol Lung Cell Mol Physiol. 2002. PMID: 12225960 Free article.
Adrenomedullin reduces endothelial hyperpermeability.
Hippenstiel S, Witzenrath M, Schmeck B, Hocke A, Krisp M, Krüll M, Seybold J, Seeger W, Rascher W, Schütte H, Suttorp N. Hippenstiel S, et al. Circ Res. 2002 Oct 4;91(7):618-25. doi: 10.1161/01.res.0000036603.61868.f9. Circ Res. 2002. PMID: 12364390
173 results