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Targeting CD70 with cusatuzumab eliminates acute myeloid leukemia stem cells in patients treated with hypomethylating agents.
Riether C, Pabst T, Höpner S, Bacher U, Hinterbrandner M, Banz Y, Müller R, Manz MG, Gharib WH, Francisco D, Bruggmann R, van Rompaey L, Moshir M, Delahaye T, Gandini D, Erzeel E, Hultberg A, Fung S, de Haard H, Leupin N, Ochsenbein AF. Riether C, et al. Among authors: hinterbrandner m. Nat Med. 2020 Sep;26(9):1459-1467. doi: 10.1038/s41591-020-0910-8. Epub 2020 Jun 29. Nat Med. 2020. PMID: 32601337 Clinical Trial.
TNIK signaling imprints CD8+ T cell memory formation early after priming.
Jaeger-Ruckstuhl CA, Hinterbrandner M, Höpner S, Correnti CE, Lüthi U, Friedli O, Freigang S, Al Sayed MF, Bührer ED, Amrein MA, Schürch CM, Radpour R, Riether C, Ochsenbein AF. Jaeger-Ruckstuhl CA, et al. Among authors: hinterbrandner m. Nat Commun. 2020 Apr 2;11(1):1632. doi: 10.1038/s41467-020-15413-7. Nat Commun. 2020. PMID: 32242021 Free PMC article.
Eosinophils regulate adipose tissue inflammation and sustain physical and immunological fitness in old age.
Brigger D, Riether C, van Brummelen R, Mosher KI, Shiu A, Ding Z, Zbären N, Gasser P, Guntern P, Yousef H, Castellano JM, Storni F, Graff-Radford N, Britschgi M, Grandgirard D, Hinterbrandner M, Siegrist M, Moullan N, Hofstetter W, Leib SL, Villiger PM, Auwerx J, Villeda SA, Wyss-Coray T, Noti M, Eggel A. Brigger D, et al. Among authors: hinterbrandner m. Nat Metab. 2020 Aug;2(8):688-702. doi: 10.1038/s42255-020-0228-3. Epub 2020 Jul 6. Nat Metab. 2020. PMID: 32694825 Free PMC article.