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TGFβ carrying exosomes in plasma: potential biomarkers of cancer progression in patients with head and neck squamous cell carcinoma.
Ludwig N, Yerneni SS, Harasymczuk M, Szczepański MJ, Głuszko A, Kukwa W, Jordan T, Spanier G, Taxis J, Spoerl S, Meier JK, Hinck CS, Campbell PG, Reichert TE, Hinck AP, Whiteside TL. Ludwig N, et al. Among authors: hinck cs. Br J Cancer. 2023 May;128(9):1733-1741. doi: 10.1038/s41416-023-02184-3. Epub 2023 Feb 21. Br J Cancer. 2023. PMID: 36810911 Free PMC article.
A novel highly potent trivalent TGF-β receptor trap inhibits early-stage tumorigenesis and tumor cell invasion in murine Pten-deficient prostate glands.
Qin T, Barron L, Xia L, Huang H, Villarreal MM, Zwaagstra J, Collins C, Yang J, Zwieb C, Kodali R, Hinck CS, Kim SK, Reddick RL, Shu C, O'Connor-McCourt MD, Hinck AP, Sun LZ. Qin T, et al. Among authors: hinck cs, hinck ap. Oncotarget. 2016 Dec 27;7(52):86087-86102. doi: 10.18632/oncotarget.13343. Oncotarget. 2016. PMID: 27863384 Free PMC article.
An engineered transforming growth factor β (TGF-β) monomer that functions as a dominant negative to block TGF-β signaling.
Kim SK, Barron L, Hinck CS, Petrunak EM, Cano KE, Thangirala A, Iskra B, Brothers M, Vonberg M, Leal B, Richter B, Kodali R, Taylor AB, Du S, Barnes CO, Sulea T, Calero G, Hart PJ, Hart MJ, Demeler B, Hinck AP. Kim SK, et al. Among authors: hinck cs, hinck ap. J Biol Chem. 2017 Apr 28;292(17):7173-7188. doi: 10.1074/jbc.M116.768754. Epub 2017 Feb 22. J Biol Chem. 2017. PMID: 28228478 Free PMC article.
A structurally distinct TGF-β mimic from an intestinal helminth parasite potently induces regulatory T cells.
Johnston CJC, Smyth DJ, Kodali RB, White MPJ, Harcus Y, Filbey KJ, Hewitson JP, Hinck CS, Ivens A, Kemter AM, Kildemoes AO, Le Bihan T, Soares DC, Anderton SM, Brenn T, Wigmore SJ, Woodcock HV, Chambers RC, Hinck AP, McSorley HJ, Maizels RM. Johnston CJC, et al. Among authors: hinck cs, hinck ap. Nat Commun. 2017 Nov 23;8(1):1741. doi: 10.1038/s41467-017-01886-6. Nat Commun. 2017. PMID: 29170498 Free PMC article.
TGF-β2 uses the concave surface of its extended finger region to bind betaglycan's ZP domain via three residues specific to TGF-β and inhibin-α.
Henen MA, Mahlawat P, Zwieb C, Kodali RB, Hinck CS, Hanna RD, Krzysiak TC, Ilangovan U, Cano KE, Hinck G, Vonberg M, McCabe M, Hinck AP. Henen MA, et al. Among authors: hinck cs, hinck ap, hinck g. J Biol Chem. 2019 Mar 1;294(9):3065-3080. doi: 10.1074/jbc.RA118.005210. Epub 2018 Dec 31. J Biol Chem. 2019. PMID: 30598510 Free PMC article.
40 results