Hilgenfeld R - Search Results

1

Diastereomeric Resolution Yields Highly Potent Inhibitor of SARS-CoV-2 Main Protease.

Cooper MS, Zhang L, Ibrahim M, Zhang K, Sun X, Röske J, Göhl M, Brönstrup M, Cowell JK, Sauerhering L, Becker S, Vangeel L, Jochmans D, Neyts J, Rox K, Marsh GP, Maple HJ, Hilgenfeld R. Cooper MS, et al. Among authors: hilgenfeld r. J Med Chem. 2022 Oct 13;65(19):13328-13342. doi: 10.1021/acs.jmedchem.2c01131. Epub 2022 Sep 30. J Med Chem. 2022. PMID: 36179320 Free PMC article.

2

Coronavirus main proteinase (3CLpro) structure: basis for design of anti-SARS drugs.

Anand K, Ziebuhr J, Wadhwani P, Mesters JR, Hilgenfeld R. Anand K, et al. Among authors: hilgenfeld r. Science. 2003 Jun 13;300(5626):1763-7. doi: 10.1126/science.1085658. Epub 2003 May 13. Science. 2003. PMID: 12746549

3

A structural view of the inactivation of the SARS coronavirus main proteinase by benzotriazole esters.

Verschueren KH, Pumpor K, Anemüller S, Chen S, Mesters JR, Hilgenfeld R. Verschueren KH, et al. Among authors: hilgenfeld r. Chem Biol. 2008 Jun;15(6):597-606. doi: 10.1016/j.chembiol.2008.04.011. Chem Biol. 2008. PMID: 18559270 Free PMC article.

4

Recent advances in targeting viral proteases for the discovery of novel antivirals.

Steuber H, Hilgenfeld R. Steuber H, et al. Among authors: hilgenfeld r. Curr Top Med Chem. 2010;10(3):323-45. doi: 10.2174/156802610790725470. Curr Top Med Chem. 2010. PMID: 20166951 Review.

5

Antiviral strategies to control calicivirus infections.

Rohayem J, Bergmann M, Gebhardt J, Gould E, Tucker P, Mattevi A, Unge T, Hilgenfeld R, Neyts J. Rohayem J, et al. Among authors: hilgenfeld r. Antiviral Res. 2010 Aug;87(2):162-78. doi: 10.1016/j.antiviral.2010.05.002. Epub 2010 May 21. Antiviral Res. 2010. PMID: 20471996 Free PMC article. Review.

6

Liberation of SARS-CoV main protease from the viral polyprotein: N-terminal autocleavage does not depend on the mature dimerization mode.

Chen S, Jonas F, Shen C, Hilgenfeld R. Chen S, et al. Among authors: hilgenfeld r. Protein Cell. 2010 Jan;1(1):59-74. doi: 10.1007/s13238-010-0011-4. Epub 2010 Feb 7. Protein Cell. 2010. PMID: 21203998 Free PMC article.

7

Peptide aldehyde inhibitors challenge the substrate specificity of the SARS-coronavirus main protease.

Zhu L, George S, Schmidt MF, Al-Gharabli SI, Rademann J, Hilgenfeld R. Zhu L, et al. Among authors: hilgenfeld r. Antiviral Res. 2011 Nov;92(2):204-12. doi: 10.1016/j.antiviral.2011.08.001. Epub 2011 Aug 11. Antiviral Res. 2011. PMID: 21854807 Free PMC article.

8

3C protease of enterovirus 68: structure-based design of Michael acceptor inhibitors and their broad-spectrum antiviral effects against picornaviruses.

Tan J, George S, Kusov Y, Perbandt M, Anemüller S, Mesters JR, Norder H, Coutard B, Lacroix C, Leyssen P, Neyts J, Hilgenfeld R. Tan J, et al. Among authors: hilgenfeld r. J Virol. 2013 Apr;87(8):4339-51. doi: 10.1128/JVI.01123-12. Epub 2013 Feb 6. J Virol. 2013. PMID: 23388726 Free PMC article.

9

Application of a cell-based protease assay for testing inhibitors of picornavirus 3C proteases.

van der Linden L, Ulferts R, Nabuurs SB, Kusov Y, Liu H, George S, Lacroix C, Goris N, Lefebvre D, Lanke KH, De Clercq K, Hilgenfeld R, Neyts J, van Kuppeveld FJ. van der Linden L, et al. Among authors: hilgenfeld r. Antiviral Res. 2014 Mar;103:17-24. doi: 10.1016/j.antiviral.2013.12.012. Epub 2014 Jan 4. Antiviral Res. 2014. PMID: 24393668 Free PMC article.

10

The enterovirus protease inhibitor rupintrivir exerts cross-genotypic anti-norovirus activity and clears cells from the norovirus replicon.

Rocha-Pereira J, Nascimento MS, Ma Q, Hilgenfeld R, Neyts J, Jochmans D. Rocha-Pereira J, et al. Among authors: hilgenfeld r. Antimicrob Agents Chemother. 2014 Aug;58(8):4675-81. doi: 10.1128/AAC.02546-13. Epub 2014 Jun 2. Antimicrob Agents Chemother. 2014. PMID: 24890597 Free PMC article.

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