Hilgenfeld R - Search Results

1

Peptide aldehyde inhibitors challenge the substrate specificity of the SARS-coronavirus main protease.

Zhu L, George S, Schmidt MF, Al-Gharabli SI, Rademann J, Hilgenfeld R. Zhu L, et al. Among authors: hilgenfeld r. Antiviral Res. 2011 Nov;92(2):204-12. doi: 10.1016/j.antiviral.2011.08.001. Epub 2011 Aug 11. Antiviral Res. 2011. PMID: 21854807 Free PMC article.

2

Structure of coronavirus main proteinase reveals combination of a chymotrypsin fold with an extra alpha-helical domain.

Anand K, Palm GJ, Mesters JR, Siddell SG, Ziebuhr J, Hilgenfeld R. Anand K, et al. Among authors: hilgenfeld r. EMBO J. 2002 Jul 1;21(13):3213-24. doi: 10.1093/emboj/cdf327. EMBO J. 2002. PMID: 12093723 Free PMC article.

3

Coronavirus main proteinase (3CLpro) structure: basis for design of anti-SARS drugs.

Anand K, Ziebuhr J, Wadhwani P, Mesters JR, Hilgenfeld R. Anand K, et al. Among authors: hilgenfeld r. Science. 2003 Jun 13;300(5626):1763-7. doi: 10.1126/science.1085658. Epub 2003 May 13. Science. 2003. PMID: 12746549

4

The crystal structures of severe acute respiratory syndrome virus main protease and its complex with an inhibitor.

Yang H, Yang M, Ding Y, Liu Y, Lou Z, Zhou Z, Sun L, Mo L, Ye S, Pang H, Gao GF, Anand K, Bartlam M, Hilgenfeld R, Rao Z. Yang H, et al. Among authors: hilgenfeld r. Proc Natl Acad Sci U S A. 2003 Nov 11;100(23):13190-5. doi: 10.1073/pnas.1835675100. Epub 2003 Oct 29. Proc Natl Acad Sci U S A. 2003. PMID: 14585926 Free PMC article.

5

Design of wide-spectrum inhibitors targeting coronavirus main proteases.

Yang H, Xie W, Xue X, Yang K, Ma J, Liang W, Zhao Q, Zhou Z, Pei D, Ziebuhr J, Hilgenfeld R, Yuen KY, Wong L, Gao G, Chen S, Chen Z, Ma D, Bartlam M, Rao Z. Yang H, et al. Among authors: hilgenfeld r. PLoS Biol. 2005 Oct;3(10):e324. doi: 10.1371/journal.pbio.0030324. Epub 2005 Sep 6. PLoS Biol. 2005. PMID: 16128623 Free PMC article.

6

Sometimes intermediates. Do the job!

Hilgenfeld R, Pumpor K. Hilgenfeld R, et al. Chem Biol. 2006 Mar;13(3):235-6. doi: 10.1016/j.chembiol.2006.03.002. Chem Biol. 2006. PMID: 16638527 Free PMC article. Review.

7

An efficient method for the synthesis of peptide aldehyde libraries employed in the discovery of reversible SARS coronavirus main protease (SARS-CoV Mpro) inhibitors.

Al-Gharabli SI, Shah ST, Weik S, Schmidt MF, Mesters JR, Kuhn D, Klebe G, Hilgenfeld R, Rademann J. Al-Gharabli SI, et al. Among authors: hilgenfeld r. Chembiochem. 2006 Jul;7(7):1048-55. doi: 10.1002/cbic.200500533. Chembiochem. 2006. PMID: 16688706 Free PMC article.

8

Structure and dynamics of SARS coronavirus main proteinase (Mpro).

Hilgenfeld R, Anand K, Mesters JR, Rao Z, Shen X, Jiang H, Tan J, Verschueren KH. Hilgenfeld R, et al. Adv Exp Med Biol. 2006;581:585-91. doi: 10.1007/978-0-387-33012-9_106. Adv Exp Med Biol. 2006. PMID: 17037602 Free PMC article. No abstract available.

9

The "SARS-unique domain" (SUD) of SARS coronavirus is an oligo(G)-binding protein.

Tan J, Kusov Y, Mutschall D, Tech S, Nagarajan K, Hilgenfeld R, Schmidt CL. Tan J, et al. Among authors: hilgenfeld r. Biochem Biophys Res Commun. 2007 Dec 28;364(4):877-82. doi: 10.1016/j.bbrc.2007.10.081. Epub 2007 Oct 23. Biochem Biophys Res Commun. 2007. PMID: 17976532 Free PMC article.

10

Sensitized detection of inhibitory fragments and iterative development of non-peptidic protease inhibitors by dynamic ligation screening.

Schmidt MF, Isidro-Llobet A, Lisurek M, El-Dahshan A, Tan J, Hilgenfeld R, Rademann J. Schmidt MF, et al. Among authors: hilgenfeld r. Angew Chem Int Ed Engl. 2008;47(17):3275-8. doi: 10.1002/anie.200704594. Angew Chem Int Ed Engl. 2008. PMID: 18348134 Free PMC article.

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