Evolutionary trade-off between heat shock resistance, growth at high temperature, and virulence expression in Salmonella Typhimurium.
Berdejo D, Mortier J, Cambré A, Sobota M, Van Eyken R, Kim TD, Vanoirbeek K, García Gonzalo D, Pagán R, Diard M, Aertsen A.
Berdejo D, et al.
mBio. 2024 Mar 13;15(3):e0310523. doi: 10.1128/mbio.03105-23. Epub 2024 Feb 13.
mBio. 2024.
PMID: 38349183
Free PMC article.
Interestingly, loss of DnaJ also downregulated the activity of the master virulence regulator HilD, thereby lowering the fraction of virulence-expressing cells within the population and attenuating virulence in mice. By connecting heat shock resistance evolution to attenua …
Interestingly, loss of DnaJ also downregulated the activity of the master virulence regulator HilD, thereby lowering the fraction of …