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Chronic endoplasmic reticulum stress in myotonic dystrophy type 2 promotes autoimmunity via mitochondrial DNA release.
Rösing S, Ullrich F, Meisterfeld S, Schmidt F, Mlitzko L, Croon M, Nattrass RG, Eberl N, Mahlberg J, Schlee M, Wieland A, Simon P, Hilbig D, Reuner U, Rapp A, Bremser J, Mirtschink P, Drukewitz S, Zillinger T, Beissert S, Paeschke K, Hartmann G, Trifunovic A, Bartok E, Günther C. Rösing S, et al. Among authors: hilbig d. Nat Commun. 2024 Feb 20;15(1):1534. doi: 10.1038/s41467-024-45535-1. Nat Commun. 2024. PMID: 38378748 Free PMC article.
A conserved isoleucine in the binding pocket of RIG-I controls immune tolerance to mitochondrial RNA.
de Regt AK, Anand K, Ciupka K, Bender F, Gatterdam K, Putschli B, Fusshöller D, Hilbig D, Kirchhoff A, Hunkler C, Wolter S, Grünewald A, Wallerath C, Schuberth-Wagner C, Ludwig J, Paeschke K, Bartok E, Hagelueken G, Hartmann G, Zillinger T, Geyer M, Schlee M. de Regt AK, et al. Among authors: hilbig d. Nucleic Acids Res. 2023 Nov 27;51(21):11893-11910. doi: 10.1093/nar/gkad835. Nucleic Acids Res. 2023. PMID: 37831086 Free PMC article.
Age-adjusted high-dose chemotherapy followed by autologous stem cell transplantation or conventional chemotherapy with R-MP as first-line treatment in elderly primary CNS lymphoma patients - the randomized phase III PRIMA-CNS trial.
Isbell LK, Uibeleisen R, Friedl A, Burger E, Dopatka T, Scherer F, Orban A, Lauer E, Malenica N, Semenova I, Vreden A, Valk E, Wendler J, Neumaier S, Fricker H, El Rabih AAH, Gloggengießer C, Hilbig D, Bleul S, Weis J, Gmehlin D, Backenstrass M, Wirtz S, Ihorst G, Finke J, Illerhaus G, Schorb E. Isbell LK, et al. Among authors: hilbig d. BMC Cancer. 2023 Aug 18;23(1):767. doi: 10.1186/s12885-023-11193-7. BMC Cancer. 2023. PMID: 37596517 Free PMC article. Clinical Trial.
Dual function of a secreted fungalysin metalloprotease in Ustilago maydis.
Ökmen B, Kemmerich B, Hilbig D, Wemhöner R, Aschenbroich J, Perrar A, Huesgen PF, Schipper K, Doehlemann G. Ökmen B, et al. Among authors: hilbig d. New Phytol. 2018 Oct;220(1):249-261. doi: 10.1111/nph.15265. Epub 2018 Jun 19. New Phytol. 2018. PMID: 29916208 Free article.