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CPT2 downregulation adapts HCC to lipid-rich environment and promotes carcinogenesis via acylcarnitine accumulation in obesity.
Fujiwara N, Nakagawa H, Enooku K, Kudo Y, Hayata Y, Nakatsuka T, Tanaka Y, Tateishi R, Hikiba Y, Misumi K, Tanaka M, Hayashi A, Shibahara J, Fukayama M, Arita J, Hasegawa K, Hirschfield H, Hoshida Y, Hirata Y, Otsuka M, Tateishi K, Koike K. Fujiwara N, et al. Among authors: hikiba y. Gut. 2018 Aug;67(8):1493-1504. doi: 10.1136/gutjnl-2017-315193. Epub 2018 Feb 6. Gut. 2018. PMID: 29437870 Free PMC article.
Biliary epithelial injury-induced regenerative response by IL-33 promotes cholangiocarcinogenesis from peribiliary glands.
Nakagawa H, Suzuki N, Hirata Y, Hikiba Y, Hayakawa Y, Kinoshita H, Ihara S, Uchino K, Nishikawa Y, Ijichi H, Otsuka M, Arita J, Sakamoto Y, Hasegawa K, Kokudo N, Tateishi K, Koike K. Nakagawa H, et al. Among authors: hikiba y. Proc Natl Acad Sci U S A. 2017 May 9;114(19):E3806-E3815. doi: 10.1073/pnas.1619416114. Epub 2017 Apr 24. Proc Natl Acad Sci U S A. 2017. PMID: 28439013 Free PMC article.
Mature gastric chief cells are not required for the development of metaplasia.
Kinoshita H, Hayakawa Y, Niu Z, Konishi M, Hata M, Tsuboi M, Hayata Y, Hikiba Y, Ihara S, Nakagawa H, Hirata Y, Wang TC, Koike K. Kinoshita H, et al. Among authors: hikiba y. Am J Physiol Gastrointest Liver Physiol. 2018 May 1;314(5):G583-G596. doi: 10.1152/ajpgi.00351.2017. Epub 2018 Jan 18. Am J Physiol Gastrointest Liver Physiol. 2018. PMID: 29345968 Free PMC article.
Interleukin-6 mediates epithelial-stromal interactions and promotes gastric tumorigenesis.
Kinoshita H, Hirata Y, Nakagawa H, Sakamoto K, Hayakawa Y, Takahashi R, Nakata W, Sakitani K, Serizawa T, Hikiba Y, Akanuma M, Shibata W, Maeda S, Koike K. Kinoshita H, et al. Among authors: hikiba y. PLoS One. 2013 Apr 12;8(4):e60914. doi: 10.1371/journal.pone.0060914. Print 2013. PLoS One. 2013. PMID: 23593346 Free PMC article.
Adhesive Interactions between Mononuclear Phagocytes and Intestinal Epithelium Perturb Normal Epithelial Differentiation and Serve as a Therapeutic Target in Inflammatory Bowel Disease.
Ihara S, Hirata Y, Hikiba Y, Yamashita A, Tsuboi M, Hata M, Konishi M, Suzuki N, Sakitani K, Kinoshita H, Hayakawa Y, Nakagawa H, Ijichi H, Tateishi K, Koike K. Ihara S, et al. Among authors: hikiba y. J Crohns Colitis. 2018 Nov 9;12(10):1219-1231. doi: 10.1093/ecco-jcc/jjy088. J Crohns Colitis. 2018. PMID: 29917067
Apoptosis signal-regulating kinase 1 regulates colitis and colitis-associated tumorigenesis by the innate immune responses.
Hayakawa Y, Hirata Y, Nakagawa H, Sakamoto K, Hikiba Y, Otsuka M, Ijichi H, Ikenoue T, Tateishi K, Akanuma M, Ogura K, Yoshida H, Ichijo H, Omata M, Maeda S. Hayakawa Y, et al. Among authors: hikiba y. Gastroenterology. 2010 Mar;138(3):1055-67.e1-4. doi: 10.1053/j.gastro.2009.11.015. Epub 2009 Nov 18. Gastroenterology. 2010. PMID: 19931259
59 results