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Structural delineation and computational design of SARS-CoV-2-neutralizing antibodies against Omicron subvariants.
Moriyama S, Anraku Y, Taminishi S, Adachi Y, Kuroda D, Kita S, Higuchi Y, Kirita Y, Kotaki R, Tonouchi K, Yumoto K, Suzuki T, Someya T, Fukuhara H, Kuroda Y, Yamamoto T, Onodera T, Fukushi S, Maeda K, Nakamura-Uchiyama F, Hashiguchi T, Hoshino A, Maenaka K, Takahashi Y. Moriyama S, et al. Among authors: higuchi y. Nat Commun. 2023 Jul 14;14(1):4198. doi: 10.1038/s41467-023-39890-8. Nat Commun. 2023. PMID: 37452031 Free PMC article.
Engineered ACE2 receptor therapy overcomes mutational escape of SARS-CoV-2.
Higuchi Y, Suzuki T, Arimori T, Ikemura N, Mihara E, Kirita Y, Ohgitani E, Mazda O, Motooka D, Nakamura S, Sakai Y, Itoh Y, Sugihara F, Matsuura Y, Matoba S, Okamoto T, Takagi J, Hoshino A. Higuchi Y, et al. Nat Commun. 2021 Jun 21;12(1):3802. doi: 10.1038/s41467-021-24013-y. Nat Commun. 2021. PMID: 34155214 Free PMC article.
An engineered ACE2 decoy neutralizes the SARS-CoV-2 Omicron variant and confers protection against infection in vivo.
Ikemura N, Taminishi S, Inaba T, Arimori T, Motooka D, Katoh K, Kirita Y, Higuchi Y, Li S, Suzuki T, Itoh Y, Ozaki Y, Nakamura S, Matoba S, Standley DM, Okamoto T, Takagi J, Hoshino A. Ikemura N, et al. Among authors: higuchi y. Sci Transl Med. 2022 Jun 22;14(650):eabn7737. doi: 10.1126/scitranslmed.abn7737. Epub 2022 Jun 22. Sci Transl Med. 2022. PMID: 35471044 Free PMC article.
An inhaled ACE2 decoy confers protection against SARS-CoV-2 infection in preclinical models.
Urano E, Itoh Y, Suzuki T, Sasaki T, Kishikawa JI, Akamatsu K, Higuchi Y, Sakai Y, Okamura T, Mitoma S, Sugihara F, Takada A, Kimura M, Nakao S, Hirose M, Sasaki T, Koketsu R, Tsuji S, Yanagida S, Shioda T, Hara E, Matoba S, Matsuura Y, Kanda Y, Arase H, Okada M, Takagi J, Kato T, Hoshino A, Yasutomi Y, Saito A, Okamoto T. Urano E, et al. Among authors: higuchi y. Sci Transl Med. 2023 Aug 30;15(711):eadi2623. doi: 10.1126/scitranslmed.adi2623. Epub 2023 Aug 30. Sci Transl Med. 2023. PMID: 37647387
1,705 results