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Network-based assessment of HDAC6 activity predicts preclinical and clinical responses to the HDAC6 inhibitor ricolinostat in breast cancer.
Zeleke TZ, Pan Q, Chiuzan C, Onishi M, Li Y, Tan H, Alvarez MJ, Honan E, Yang M, Chia PL, Mukhopadhyay P, Kelly S, Wu R, Fenn K, Trivedi MS, Accordino M, Crew KD, Hershman DL, Maurer M, Jones S, High A, Peng J, Califano A, Kalinsky K, Yu J, Silva J. Zeleke TZ, et al. Among authors: high a. Nat Cancer. 2023 Feb;4(2):257-275. doi: 10.1038/s43018-022-00489-5. Epub 2022 Dec 30. Nat Cancer. 2023. PMID: 36585452 Free PMC article.
Deep multiomics profiling of brain tumors identifies signaling networks downstream of cancer driver genes.
Wang H, Diaz AK, Shaw TI, Li Y, Niu M, Cho JH, Paugh BS, Zhang Y, Sifford J, Bai B, Wu Z, Tan H, Zhou S, Hover LD, Tillman HS, Shirinifard A, Thiagarajan S, Sablauer A, Pagala V, High AA, Wang X, Li C, Baker SJ, Peng J. Wang H, et al. Among authors: high aa. Nat Commun. 2019 Aug 16;10(1):3718. doi: 10.1038/s41467-019-11661-4. Nat Commun. 2019. PMID: 31420543 Free PMC article.
High throughput omics approaches provide an unprecedented opportunity for dissecting molecular mechanisms in cancer biology. ...Pathway activity computation and mouse survival indicate the NTRK1 mutation induces a higher activation of AKT downstream targets includin …
High throughput omics approaches provide an unprecedented opportunity for dissecting molecular mechanisms in cancer biology. ...Pathw …
Deep Proteome Profiling by Isobaric Labeling, Extensive Liquid Chromatography, Mass Spectrometry, and Software-assisted Quantification.
High AA, Tan H, Pagala VR, Niu M, Cho JH, Wang X, Bai B, Peng J. High AA, et al. J Vis Exp. 2017 Nov 15;(129):56474. doi: 10.3791/56474. J Vis Exp. 2017. PMID: 29286450 Free PMC article.
This protocol includes the following main steps: protein extraction and digestion, TMT labeling, 2-dimensional (2D) LC, high-resolution mass spectrometry, and computational data processing. ...This protocol can also be applied to the quantitation of post translational modi …
This protocol includes the following main steps: protein extraction and digestion, TMT labeling, 2-dimensional (2D) LC, high-resoluti …
Deep undepleted human serum proteome profiling toward biomarker discovery for Alzheimer's disease.
Dey KK, Wang H, Niu M, Bai B, Wang X, Li Y, Cho JH, Tan H, Mishra A, High AA, Chen PC, Wu Z, Beach TG, Peng J. Dey KK, et al. Among authors: high aa. Clin Proteomics. 2019 Apr 17;16:16. doi: 10.1186/s12014-019-9237-1. eCollection 2019. Clin Proteomics. 2019. PMID: 31019427 Free PMC article.
BACKGROUND: Blood-based protein measurement is a routine practice for detecting biomarkers in human disease. Comprehensive profiling of blood/plasma/serum proteome is a challenge due to an extremely large dynamic range, as exemplified by a small subset of hig …
BACKGROUND: Blood-based protein measurement is a routine practice for detecting biomarkers in human disease. Comprehensive profiling …
Quantitative protein analysis by mass spectrometry.
Pagala VR, High AA, Wang X, Tan H, Kodali K, Mishra A, Kavdia K, Xu Y, Wu Z, Peng J. Pagala VR, et al. Among authors: high aa. Methods Mol Biol. 2015;1278:281-305. doi: 10.1007/978-1-4939-2425-7_17. Methods Mol Biol. 2015. PMID: 25859956
Deep Profiling of Proteome and Phosphoproteome by Isobaric Labeling, Extensive Liquid Chromatography, and Mass Spectrometry.
Bai B, Tan H, Pagala VR, High AA, Ichhaporia VP, Hendershot L, Peng J. Bai B, et al. Among authors: high aa. Methods Enzymol. 2017;585:377-395. doi: 10.1016/bs.mie.2016.10.007. Epub 2016 Dec 24. Methods Enzymol. 2017. PMID: 28109439 Free PMC article.
The major steps include protein extraction and digestion, TMT labeling, two-dimensional liquid chromatography, TiO(2)-mediated phosphopeptide enrichment, high-resolution mass spectrometry, and computational data processing. ...Quality control steps are implemented for trou …
The major steps include protein extraction and digestion, TMT labeling, two-dimensional liquid chromatography, TiO(2)-mediated phosphopeptid …
Integrative network analysis reveals USP7 haploinsufficiency inhibits E-protein activity in pediatric T-lineage acute lymphoblastic leukemia (T-ALL).
Shaw TI, Dong L, Tian L, Qian C, Liu Y, Ju B, High A, Kavdia K, Pagala VR, Shaner B, Pei D, Easton J, Janke LJ, Porter SN, Ma X, Cheng C, Pruett-Miller SM, Choi J, Yu J, Peng J, Gu W, Look AT, Downing JR, Zhang J. Shaw TI, et al. Among authors: high a. Sci Rep. 2021 Mar 4;11(1):5154. doi: 10.1038/s41598-021-84647-2. Sci Rep. 2021. PMID: 33664368 Free PMC article.
Deep Multilayer Brain Proteomics Identifies Molecular Networks in Alzheimer's Disease Progression.
Bai B, Wang X, Li Y, Chen PC, Yu K, Dey KK, Yarbro JM, Han X, Lutz BM, Rao S, Jiao Y, Sifford JM, Han J, Wang M, Tan H, Shaw TI, Cho JH, Zhou S, Wang H, Niu M, Mancieri A, Messler KA, Sun X, Wu Z, Pagala V, High AA, Bi W, Zhang H, Chi H, Haroutunian V, Zhang B, Beach TG, Yu G, Peng J. Bai B, et al. Among authors: high aa. Neuron. 2020 Mar 18;105(6):975-991.e7. doi: 10.1016/j.neuron.2019.12.015. Epub 2020 Jan 8. Neuron. 2020. PMID: 31926610 Free PMC article.
160 results