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Supermeres are functional extracellular nanoparticles replete with disease biomarkers and therapeutic targets.
Zhang Q, Jeppesen DK, Higginbotham JN, Graves-Deal R, Trinh VQ, Ramirez MA, Sohn Y, Neininger AC, Taneja N, McKinley ET, Niitsu H, Cao Z, Evans R, Glass SE, Ray KC, Fissell WH, Hill S, Rose KL, Huh WJ, Washington MK, Ayers GD, Burnette DT, Sharma S, Rome LH, Franklin JL, Lee YA, Liu Q, Coffey RJ. Zhang Q, et al. Among authors: higginbotham jn. Nat Cell Biol. 2021 Dec;23(12):1240-1254. doi: 10.1038/s41556-021-00805-8. Epub 2021 Dec 9. Nat Cell Biol. 2021. PMID: 34887515 Free PMC article.
Use of fluorescence-activated vesicle sorting for isolation of Naked2-associated, basolaterally targeted exocytic vesicles for proteomics analysis.
Cao Z, Li C, Higginbotham JN, Franklin JL, Tabb DL, Graves-Deal R, Hill S, Cheek K, Jerome WG, Lapierre LA, Goldenring JR, Ham AJ, Coffey RJ. Cao Z, et al. Among authors: higginbotham jn. Mol Cell Proteomics. 2008 Sep;7(9):1651-67. doi: 10.1074/mcp.M700155-MCP200. Epub 2008 May 25. Mol Cell Proteomics. 2008. PMID: 18504258 Free PMC article.
The enterocyte microvillus is a vesicle-generating organelle.
McConnell RE, Higginbotham JN, Shifrin DA Jr, Tabb DL, Coffey RJ, Tyska MJ. McConnell RE, et al. Among authors: higginbotham jn. J Cell Biol. 2009 Jun 29;185(7):1285-98. doi: 10.1083/jcb.200902147. J Cell Biol. 2009. PMID: 19564407 Free PMC article.
Amphiregulin exosomes increase cancer cell invasion.
Higginbotham JN, Demory Beckler M, Gephart JD, Franklin JL, Bogatcheva G, Kremers GJ, Piston DW, Ayers GD, McConnell RE, Tyska MJ, Coffey RJ. Higginbotham JN, et al. Curr Biol. 2011 May 10;21(9):779-86. doi: 10.1016/j.cub.2011.03.043. Epub 2011 Apr 21. Curr Biol. 2011. PMID: 21514161 Free PMC article.
KRAS-dependent sorting of miRNA to exosomes.
Cha DJ, Franklin JL, Dou Y, Liu Q, Higginbotham JN, Demory Beckler M, Weaver AM, Vickers K, Prasad N, Levy S, Zhang B, Coffey RJ, Patton JG. Cha DJ, et al. Among authors: higginbotham jn. Elife. 2015 Jul 1;4:e07197. doi: 10.7554/eLife.07197. Elife. 2015. PMID: 26132860 Free PMC article.
45 results