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Functionally confirmed compound heterozygous ADAM17 missense loss-of-function variants cause neonatal inflammatory skin and bowel disease 1.
Imoto I, Saito M, Suga K, Kohmoto T, Otsu M, Horiuchi K, Nakayama H, Higashiyama S, Sugimoto M, Sasaki A, Homma Y, Shono M, Nakagawa R, Hayabuchi Y, Tange S, Kagami S, Masuda K. Imoto I, et al. Among authors: higashiyama s. Sci Rep. 2021 May 5;11(1):9552. doi: 10.1038/s41598-021-89063-0. Sci Rep. 2021. PMID: 33953303 Free PMC article.
Cullin 3 regulates ADAMs-mediated ectodomain shedding of amphiregulin.
Nakayama H, Sakaue T, Maekawa M, Fujisaki A, Higashiyama S. Nakayama H, et al. Among authors: higashiyama s. Biochem Biophys Res Commun. 2018 Apr 30;499(1):17-23. doi: 10.1016/j.bbrc.2018.03.097. Epub 2018 Mar 21. Biochem Biophys Res Commun. 2018. PMID: 29550478
Insufficiency of pro-heparin-binding epidermal growth factor-like growth factor shedding enhances hypoxic cell death in H9c2 cardiomyoblasts via the activation of caspase-3 and c-Jun N-terminal kinase.
Uetani T, Nakayama H, Okayama H, Okura T, Higaki J, Inoue H, Higashiyama S. Uetani T, et al. Among authors: higashiyama s. J Biol Chem. 2009 May 1;284(18):12399-409. doi: 10.1074/jbc.M900463200. Epub 2009 Feb 4. J Biol Chem. 2009. PMID: 19193634 Free PMC article.
380 results