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Alanine substitutions in the GXXXG motif alter C99 cleavage by γ-secretase but not its dimerization.
J Neurochem. 2017 Mar;140(6):955-962. doi: 10.1111/jnc.13942. Epub 2017 Jan 30.
J Neurochem. 2017.
PMID: 28032911
Free article.
Glycosylation status of nicastrin influences catalytic activity and substrate preference of γ-secretase.
Moniruzzaman M, Ishihara S, Nobuhara M, Higashide H, Funamoto S.
Moniruzzaman M, et al. Among authors: higashide h.
Biochem Biophys Res Commun. 2018 Jul 7;502(1):98-103. doi: 10.1016/j.bbrc.2018.05.126. Epub 2018 May 25.
Biochem Biophys Res Commun. 2018.
PMID: 29787759
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