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Structural basis of pharmacological chaperoning for human β-galactosidase.
Suzuki H, Ohto U, Higaki K, Mena-Barragán T, Aguilar-Moncayo M, Ortiz Mellet C, Nanba E, Garcia Fernandez JM, Suzuki Y, Shimizu T. Suzuki H, et al. Among authors: higaki k. J Biol Chem. 2014 May 23;289(21):14560-8. doi: 10.1074/jbc.M113.529529. Epub 2014 Apr 15. J Biol Chem. 2014. PMID: 24737316 Free PMC article.
A bicyclic 1-deoxygalactonojirimycin derivative as a novel pharmacological chaperone for GM1 gangliosidosis.
Takai T, Higaki K, Aguilar-Moncayo M, Mena-Barragán T, Hirano Y, Yura K, Yu L, Ninomiya H, García-Moreno MI, Sakakibara Y, Ohno K, Nanba E, Ortiz Mellet C, García Fernández JM, Suzuki Y. Takai T, et al. Among authors: higaki k. Mol Ther. 2013 Mar;21(3):526-32. doi: 10.1038/mt.2012.263. Epub 2013 Jan 22. Mol Ther. 2013. PMID: 23337983 Free PMC article.
Molecular basis of 1-deoxygalactonojirimycin arylthiourea binding to human α-galactosidase a: pharmacological chaperoning efficacy on Fabry disease mutants.
Yu Y, Mena-Barragán T, Higaki K, Johnson JL, Drury JE, Lieberman RL, Nakasone N, Ninomiya H, Tsukimura T, Sakuraba H, Suzuki Y, Nanba E, Mellet CO, García Fernández JM, Ohno K. Yu Y, et al. Among authors: higaki k. ACS Chem Biol. 2014 Jul 18;9(7):1460-9. doi: 10.1021/cb500143h. Epub 2014 May 12. ACS Chem Biol. 2014. PMID: 24783948
Inhibitor versus chaperone behaviour of d-fagomine, DAB and LAB sp(2)-iminosugar conjugates against glycosidases: A structure-activity relationship study in Gaucher fibroblasts.
Mena-Barragán T, García-Moreno MI, Nanba E, Higaki K, Concia AL, Clapés P, García Fernández JM, Ortiz Mellet C. Mena-Barragán T, et al. Among authors: higaki k. Eur J Med Chem. 2016 Oct 4;121:880-891. doi: 10.1016/j.ejmech.2015.08.038. Epub 2015 Aug 31. Eur J Med Chem. 2016. PMID: 26361824
pH-Responsive Pharmacological Chaperones for Rescuing Mutant Glycosidases.
Mena-Barragán T, Narita A, Matias D, Tiscornia G, Nanba E, Ohno K, Suzuki Y, Higaki K, Garcia Fernández JM, Ortiz Mellet C. Mena-Barragán T, et al. Among authors: higaki k. Angew Chem Int Ed Engl. 2015 Sep 28;54(40):11696-700. doi: 10.1002/anie.201505147. Epub 2015 Aug 7. Angew Chem Int Ed Engl. 2015. PMID: 26386364
Efficient stereoselective synthesis of 2-acetamido-1,2-dideoxyallonojirimycin (DAJNAc) and sp(2)-iminosugar conjugates: Novel hexosaminidase inhibitors with discrimination capabilities between the mature and precursor forms of the enzyme.
de la Fuente A, Rísquez-Cuadro R, Verdaguer X, García Fernández JM, Nanba E, Higaki K, Ortiz Mellet C, Riera A. de la Fuente A, et al. Among authors: higaki k. Eur J Med Chem. 2016 Oct 4;121:926-938. doi: 10.1016/j.ejmech.2015.10.038. Epub 2015 Oct 26. Eur J Med Chem. 2016. PMID: 26564401 Free article.
Pharmacological Chaperones for the Treatment of α-Mannosidosis.
Rísquez-Cuadro R, Matsumoto R, Ortega-Caballero F, Nanba E, Higaki K, García Fernández JM, Ortiz Mellet C. Rísquez-Cuadro R, et al. Among authors: higaki k. J Med Chem. 2019 Jun 27;62(12):5832-5843. doi: 10.1021/acs.jmedchem.9b00153. Epub 2019 May 2. J Med Chem. 2019. PMID: 31017416
Tuning glycosidase inhibition through aglycone interactions: pharmacological chaperones for Fabry disease and GM1 gangliosidosis.
Aguilar-Moncayo M, Takai T, Higaki K, Mena-Barragán T, Hirano Y, Yura K, Li L, Yu Y, Ninomiya H, García-Moreno MI, Ishii S, Sakakibara Y, Ohno K, Nanba E, Ortiz Mellet C, García Fernández JM, Suzuki Y. Aguilar-Moncayo M, et al. Among authors: higaki k. Chem Commun (Camb). 2012 Jul 4;48(52):6514-6. doi: 10.1039/c2cc32065g. Epub 2012 May 23. Chem Commun (Camb). 2012. PMID: 22618082
377 results