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CX-5461 is a DNA G-quadruplex stabilizer with selective lethality in BRCA1/2 deficient tumours.
Xu H, Di Antonio M, McKinney S, Mathew V, Ho B, O'Neil NJ, Santos ND, Silvester J, Wei V, Garcia J, Kabeer F, Lai D, Soriano P, Banáth J, Chiu DS, Yap D, Le DD, Ye FB, Zhang A, Thu K, Soong J, Lin SC, Tsai AH, Osako T, Algara T, Saunders DN, Wong J, Xian J, Bally MB, Brenton JD, Brown GW, Shah SP, Cescon D, Mak TW, Caldas C, Stirling PC, Hieter P, Balasubramanian S, Aparicio S. Xu H, et al. Among authors: hieter p. Nat Commun. 2017 Feb 17;8:14432. doi: 10.1038/ncomms14432. Nat Commun. 2017. PMID: 28211448 Free PMC article.
Synthetic lethality and cancer.
O'Neil NJ, Bailey ML, Hieter P. O'Neil NJ, et al. Among authors: hieter p. Nat Rev Genet. 2017 Oct;18(10):613-623. doi: 10.1038/nrg.2017.47. Epub 2017 Jun 26. Nat Rev Genet. 2017. PMID: 28649135 Review.
Synthetic lethality of cohesins with PARPs and replication fork mediators.
McLellan JL, O'Neil NJ, Barrett I, Ferree E, van Pel DM, Ushey K, Sipahimalani P, Bryan J, Rose AM, Hieter P. McLellan JL, et al. Among authors: hieter p. PLoS Genet. 2012;8(3):e1002574. doi: 10.1371/journal.pgen.1002574. Epub 2012 Mar 8. PLoS Genet. 2012. PMID: 22412391 Free PMC article.
202 results