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Empirical identification and validation of tumor-targeting T cell receptors from circulation using autologous pancreatic tumor organoids.
Meng Q, Xie S, Gray GK, Dezfulian MH, Li W, Huang L, Akshinthala D, Ferrer E, Conahan C, Perea Del Pino S, Grossman J, Elledge SJ, Hidalgo M, Muthuswamy SK. Meng Q, et al. Among authors: hidalgo m. J Immunother Cancer. 2021 Nov;9(11):e003213. doi: 10.1136/jitc-2021-003213. J Immunother Cancer. 2021. PMID: 34789550 Free PMC article.
Personalized RNA Medicine for Pancreatic Cancer.
Gilles ME, Hao L, Huang L, Rupaimoole R, Lopez-Casas PP, Pulver E, Jeong JC, Muthuswamy SK, Hidalgo M, Bhatia SN, Slack FJ. Gilles ME, et al. Among authors: hidalgo m. Clin Cancer Res. 2018 Apr 1;24(7):1734-1747. doi: 10.1158/1078-0432.CCR-17-2733. Epub 2018 Jan 12. Clin Cancer Res. 2018. PMID: 29330203
Discovery of New Targets to Control Metastasis in Pancreatic Cancer by Single-cell Transcriptomics Analysis of Circulating Tumor Cells.
Dimitrov-Markov S, Perales-Patón J, Bockorny B, Dopazo A, Muñoz M, Baños N, Bonilla V, Menendez C, Duran Y, Huang L, Perea S, Muthuswamy SK, Al-Shahrour F, Lopez-Casas PP, Hidalgo M. Dimitrov-Markov S, et al. Among authors: hidalgo m. Mol Cancer Ther. 2020 Aug;19(8):1751-1760. doi: 10.1158/1535-7163.MCT-19-1166. Epub 2020 Jun 4. Mol Cancer Ther. 2020. PMID: 32499301
PDX-derived organoids model in vivo drug response and secrete biomarkers.
Huang L, Bockorny B, Paul I, Akshinthala D, Frappart PO, Gandarilla O, Bose A, Sanchez-Gonzalez V, Rouse EE, Lehoux SD, Pandell N, Lim CM, Clohessy JG, Grossman J, Gonzalez R, Del Pino SP, Daaboul G, Sawhney MS, Freedman SD, Kleger A, Cummings RD, Emili A, Muthuswamy LB, Hidalgo M, Muthuswamy SK. Huang L, et al. Among authors: hidalgo m. JCI Insight. 2020 Nov 5;5(21):e135544. doi: 10.1172/jci.insight.135544. JCI Insight. 2020. PMID: 32990680 Free PMC article.
Targeting Pin1 renders pancreatic cancer eradicable by synergizing with immunochemotherapy.
Koikawa K, Kibe S, Suizu F, Sekino N, Kim N, Manz TD, Pinch BJ, Akshinthala D, Verma A, Gaglia G, Nezu Y, Ke S, Qiu C, Ohuchida K, Oda Y, Lee TH, Wegiel B, Clohessy JG, London N, Santagata S, Wulf GM, Hidalgo M, Muthuswamy SK, Nakamura M, Gray NS, Zhou XZ, Lu KP. Koikawa K, et al. Among authors: hidalgo m. Cell. 2021 Sep 2;184(18):4753-4771.e27. doi: 10.1016/j.cell.2021.07.020. Epub 2021 Aug 12. Cell. 2021. PMID: 34388391 Free PMC article.
Organoid Sensitivity Correlates with Therapeutic Response in Patients with Pancreatic Cancer.
Grossman JE, Muthuswamy L, Huang L, Akshinthala D, Perea S, Gonzalez RS, Tsai LL, Cohen J, Bockorny B, Bullock AJ, Schlechter B, Peters MLB, Conahan C, Narasimhan S, Lim C, Davis RB, Besaw R, Sawhney MS, Pleskow D, Berzin TM, Smith M, Kent TS, Callery M, Muthuswamy SK, Hidalgo M. Grossman JE, et al. Among authors: hidalgo m. Clin Cancer Res. 2022 Feb 15;28(4):708-718. doi: 10.1158/1078-0432.CCR-20-4116. Clin Cancer Res. 2022. PMID: 34789479 Free PMC article.
Personalized tumor vaccine for pancreatic cancer.
Orr S, Huang L, Moser J, Stroopinsky D, Gandarilla O, DeCicco C, Liegel J, Tacettin C, Ephraim A, Cheloni G, Torres D, Kufe D, Rosenblatt J, Hidalgo M, Muthuswamy SK, Avigan D. Orr S, et al. Among authors: hidalgo m. Cancer Immunol Immunother. 2023 Feb;72(2):301-313. doi: 10.1007/s00262-022-03237-x. Epub 2022 Jul 14. Cancer Immunol Immunother. 2023. PMID: 35834008 Free PMC article.
Elevated levels of mitochondrial CoQ10 induce ROS-mediated apoptosis in pancreatic cancer.
Dadali T, Diers AR, Kazerounian S, Muthuswamy SK, Awate P, Ng R, Mogre S, Spencer C, Krumova K, Rockwell HE, McDaniel J, Chen EY, Gao F, Diedrich KT, Vemulapalli V, Rodrigues LO, Akmaev VR, Thapa K, Hidalgo M, Bose A, Vishnudas VK, Moser AJ, Granger E, Kiebish MA, Gesta S, Narain NR, Sarangarajan R. Dadali T, et al. Among authors: hidalgo m. Sci Rep. 2021 Mar 11;11(1):5749. doi: 10.1038/s41598-021-84852-z. Sci Rep. 2021. PMID: 33707480 Free PMC article.
OMTX705, a Novel FAP-Targeting ADC Demonstrates Activity in Chemotherapy and Pembrolizumab-Resistant Solid Tumor Models.
Fabre M, Ferrer C, Domínguez-Hormaetxe S, Bockorny B, Murias L, Seifert O, Eisler SA, Kontermann RE, Pfizenmaier K, Lee SY, Vivanco MD, López-Casas PP, Perea S, Abbas M, Richter W, Simon L, Hidalgo M. Fabre M, et al. Among authors: hidalgo m. Clin Cancer Res. 2020 Jul 1;26(13):3420-3430. doi: 10.1158/1078-0432.CCR-19-2238. Epub 2020 Mar 11. Clin Cancer Res. 2020. PMID: 32161121
A Tricin Derivative from Deschampsia antarctica Desv. Inhibits Colorectal Carcinoma Growth and Liver Metastasis through the Induction of a Specific Immune Response.
Malvicini M, Gutierrez-Moraga A, Rodriguez MM, Gomez-Bustillo S, Salazar L, Sunkel C, Nozal L, Salgado A, Hidalgo M, Lopez-Casas PP, Novella JL, Vaquero JJ, Alvarez-Builla J, Mora A, Gidekel M, Mazzolini G. Malvicini M, et al. Among authors: hidalgo m. Mol Cancer Ther. 2018 May;17(5):966-976. doi: 10.1158/1535-7163.MCT-17-0193. Epub 2018 Feb 26. Mol Cancer Ther. 2018. PMID: 29483221
1,202 results