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Nodal/Activin signaling drives self-renewal and tumorigenicity of pancreatic cancer stem cells and provides a target for combined drug therapy.
Lonardo E, Hermann PC, Mueller MT, Huber S, Balic A, Miranda-Lorenzo I, Zagorac S, Alcala S, Rodriguez-Arabaolaza I, Ramirez JC, Torres-Ruíz R, Garcia E, Hidalgo M, Cebrián DÁ, Heuchel R, Löhr M, Berger F, Bartenstein P, Aicher A, Heeschen C. Lonardo E, et al. Among authors: hidalgo m. Cell Stem Cell. 2011 Nov 4;9(5):433-46. doi: 10.1016/j.stem.2011.10.001. Cell Stem Cell. 2011. PMID: 22056140 Free article.
Intracellular autofluorescence: a biomarker for epithelial cancer stem cells.
Miranda-Lorenzo I, Dorado J, Lonardo E, Alcala S, Serrano AG, Clausell-Tormos J, Cioffi M, Megias D, Zagorac S, Balic A, Hidalgo M, Erkan M, Kleeff J, Scarpa A, Sainz B Jr, Heeschen C. Miranda-Lorenzo I, et al. Among authors: hidalgo m. Nat Methods. 2014 Nov;11(11):1161-9. doi: 10.1038/nmeth.3112. Epub 2014 Sep 28. Nat Methods. 2014. PMID: 25262208
Microenvironmental hCAP-18/LL-37 promotes pancreatic ductal adenocarcinoma by activating its cancer stem cell compartment.
Sainz B Jr, Alcala S, Garcia E, Sanchez-Ripoll Y, Azevedo MM, Cioffi M, Tatari M, Miranda-Lorenzo I, Hidalgo M, Gomez-Lopez G, Cañamero M, Erkan M, Kleeff J, García-Silva S, Sancho P, Hermann PC, Heeschen C. Sainz B Jr, et al. Among authors: hidalgo m. Gut. 2015 Dec;64(12):1921-35. doi: 10.1136/gutjnl-2014-308935. Epub 2015 Apr 3. Gut. 2015. PMID: 25841238
Combined targeted treatment to eliminate tumorigenic cancer stem cells in human pancreatic cancer.
Mueller MT, Hermann PC, Witthauer J, Rubio-Viqueira B, Leicht SF, Huber S, Ellwart JW, Mustafa M, Bartenstein P, D'Haese JG, Schoenberg MH, Berger F, Jauch KW, Hidalgo M, Heeschen C. Mueller MT, et al. Among authors: hidalgo m. Gastroenterology. 2009 Sep;137(3):1102-13. doi: 10.1053/j.gastro.2009.05.053. Epub 2009 Jun 6. Gastroenterology. 2009. PMID: 19501590
Inhibition of ataxia telangiectasia- and Rad3-related function abrogates the in vitro and in vivo tumorigenicity of human colon cancer cells through depletion of the CD133(+) tumor-initiating cell fraction.
Gallmeier E, Hermann PC, Mueller MT, Machado JG, Ziesch A, De Toni EN, Palagyi A, Eisen C, Ellwart JW, Rivera J, Rubio-Viqueira B, Hidalgo M, Bunz F, Göke B, Heeschen C. Gallmeier E, et al. Among authors: hidalgo m. Stem Cells. 2011 Mar;29(3):418-29. doi: 10.1002/stem.595. Stem Cells. 2011. PMID: 21308861
1,202 results