Hicks KO - Search Results

1

Selectively Targeting Tumor Hypoxia With the Hypoxia-Activated Prodrug CP-506.

van der Wiel AMA, Jackson-Patel V, Niemans R, Yaromina A, Liu E, Marcus D, Mowday AM, Lieuwes NG, Biemans R, Lin X, Fu Z, Kumara S, Jochems A, Ashoorzadeh A, Anderson RF, Hicks KO, Bull MR, Abbattista MR, Guise CP, Deschoemaeker S, Thiolloy S, Heyerick A, Solivio MJ, Balbo S, Smaill JB, Theys J, Dubois LJ, Patterson AV, Lambin P. van der Wiel AMA, et al. Among authors: hicks ko. Mol Cancer Ther. 2021 Dec;20(12):2372-2383. doi: 10.1158/1535-7163.MCT-21-0406. Epub 2021 Oct 8. Mol Cancer Ther. 2021. PMID: 34625504 Free PMC article.

2

In vitro and in vivo models for evaluation of GDEPT: quantifying bystander killing in cell cultures and tumors.

Wilson WR, Pullen SM, Hogg A, Hobbs SM, Pruijn FB, Hicks KO. Wilson WR, et al. Among authors: hicks ko. Methods Mol Med. 2004;90:403-31. doi: 10.1385/1-59259-429-8:403. Methods Mol Med. 2004. PMID: 14657576 No abstract available.

3

Use of three-dimensional tissue cultures to model extravascular transport and predict in vivo activity of hypoxia-targeted anticancer drugs.

Hicks KO, Pruijn FB, Secomb TW, Hay MP, Hsu R, Brown JM, Denny WA, Dewhirst MW, Wilson WR. Hicks KO, et al. J Natl Cancer Inst. 2006 Aug 16;98(16):1118-28. doi: 10.1093/jnci/djj306. J Natl Cancer Inst. 2006. PMID: 16912264

4

Bystander effects of bioreductive drugs: potential for exploiting pathological tumor hypoxia with dinitrobenzamide mustards.

Wilson WR, Hicks KO, Pullen SM, Ferry DM, Helsby NA, Patterson AV. Wilson WR, et al. Among authors: hicks ko. Radiat Res. 2007 Jun;167(6):625-36. doi: 10.1667/RR0807.1. Radiat Res. 2007. PMID: 17523848

5

Mechanism of action and preclinical antitumor activity of the novel hypoxia-activated DNA cross-linking agent PR-104.

Patterson AV, Ferry DM, Edmunds SJ, Gu Y, Singleton RS, Patel K, Pullen SM, Hicks KO, Syddall SP, Atwell GJ, Yang S, Denny WA, Wilson WR. Patterson AV, et al. Among authors: hicks ko. Clin Cancer Res. 2007 Jul 1;13(13):3922-32. doi: 10.1158/1078-0432.CCR-07-0478. Clin Cancer Res. 2007. PMID: 17606726

6

Oxygen dependence and extravascular transport of hypoxia-activated prodrugs: comparison of the dinitrobenzamide mustard PR-104A and tirapazamine.

Hicks KO, Myint H, Patterson AV, Pruijn FB, Siim BG, Patel K, Wilson WR. Hicks KO, et al. Int J Radiat Oncol Biol Phys. 2007 Oct 1;69(2):560-71. doi: 10.1016/j.ijrobp.2007.05.049. Int J Radiat Oncol Biol Phys. 2007. PMID: 17869669

7

Pharmacokinetic/pharmacodynamic model-guided identification of hypoxia-selective 1,2,4-benzotriazine 1,4-dioxides with antitumor activity: the role of extravascular transport.

Hay MP, Hicks KO, Pruijn FB, Pchalek K, Siim BG, Wilson WR, Denny WA. Hay MP, et al. Among authors: hicks ko. J Med Chem. 2007 Dec 13;50(25):6392-404. doi: 10.1021/jm070670g. Epub 2007 Nov 15. J Med Chem. 2007. PMID: 18001018

8

Hypoxia-selective 3-alkyl 1,2,4-benzotriazine 1,4-dioxides: the influence of hydrogen bond donors on extravascular transport and antitumor activity.

Hay MP, Pchalek K, Pruijn FB, Hicks KO, Siim BG, Anderson RF, Shinde SS, Phillips V, Denny WA, Wilson WR. Hay MP, et al. Among authors: hicks ko. J Med Chem. 2007 Dec 27;50(26):6654-64. doi: 10.1021/jm701037w. Epub 2007 Dec 6. J Med Chem. 2007. PMID: 18052317

9

Tricyclic [1,2,4]triazine 1,4-dioxides as hypoxia selective cytotoxins.

Hay MP, Hicks KO, Pchalek K, Lee HH, Blaser A, Pruijn FB, Anderson RF, Shinde SS, Wilson WR, Denny WA. Hay MP, et al. Among authors: hicks ko. J Med Chem. 2008 Nov 13;51(21):6853-65. doi: 10.1021/jm800967h. Epub 2008 Oct 11. J Med Chem. 2008. PMID: 18847185 Free PMC article.

10

A combined pharmacokinetic model for the hypoxia-targeted prodrug PR-104A in humans, dogs, rats and mice predicts species differences in clearance and toxicity.

Patel K, Choy SS, Hicks KO, Melink TJ, Holford NH, Wilson WR. Patel K, et al. Among authors: hicks ko. Cancer Chemother Pharmacol. 2011 May;67(5):1145-55. doi: 10.1007/s00280-010-1412-z. Epub 2010 Aug 4. Cancer Chemother Pharmacol. 2011. PMID: 20683596

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