Hicks KO - Search Results

1

Pharmacokinetic and anti-cancer properties of high dose ascorbate in solid tumours of ascorbate-dependent mice.

Campbell EJ, Vissers MCM, Wohlrab C, Hicks KO, Strother RM, Bozonet SM, Robinson BA, Dachs GU. Campbell EJ, et al. Among authors: hicks ko. Free Radic Biol Med. 2016 Oct;99:451-462. doi: 10.1016/j.freeradbiomed.2016.08.027. Epub 2016 Aug 24. Free Radic Biol Med. 2016. PMID: 27567539

2

Hypoxia-directed drug strategies to target the tumor microenvironment.

Hay MP, Hicks KO, Wang J. Hay MP, et al. Among authors: hicks ko. Adv Exp Med Biol. 2014;772:111-45. doi: 10.1007/978-1-4614-5915-6_6. Adv Exp Med Biol. 2014. PMID: 24272357 Review.

3

Pharmacokinetic modeling of ascorbate diffusion through normal and tumor tissue.

Kuiper C, Vissers MC, Hicks KO. Kuiper C, et al. Among authors: hicks ko. Free Radic Biol Med. 2014 Dec;77:340-52. doi: 10.1016/j.freeradbiomed.2014.09.023. Epub 2014 Sep 30. Free Radic Biol Med. 2014. PMID: 25277418

4

Restoring Tumour Selectivity of the Bioreductive Prodrug PR-104 by Developing an Analogue Resistant to Aerobic Metabolism by Human Aldo-Keto Reductase 1C3.

Abbattista MR, Ashoorzadeh A, Guise CP, Mowday AM, Mittra R, Silva S, Hicks KO, Bull MR, Jackson-Patel V, Lin X, Prosser GA, Lambie NK, Dachs GU, Ackerley DF, Smaill JB, Patterson AV. Abbattista MR, et al. Among authors: hicks ko. Pharmaceuticals (Basel). 2021 Nov 26;14(12):1231. doi: 10.3390/ph14121231. Pharmaceuticals (Basel). 2021. PMID: 34959631 Free PMC article.

5

Efficient Protocol for the Identification of Hypoxic Cell Radiosensitisers.

Hong CR, Wang J, Hicks KO, Hay MP. Hong CR, et al. Among authors: hicks ko. Adv Exp Med Biol. 2016;899:269-90. doi: 10.1007/978-3-319-26666-4_16. Adv Exp Med Biol. 2016. PMID: 27325273

6

An Intratumor Pharmacokinetic/Pharmacodynamic Model for the Hypoxia-Activated Prodrug Evofosfamide (TH-302): Monotherapy Activity is Not Dependent on a Bystander Effect.

Hong CR, Wilson WR, Hicks KO. Hong CR, et al. Among authors: hicks ko. Neoplasia. 2019 Feb;21(2):159-171. doi: 10.1016/j.neo.2018.11.009. Epub 2018 Dec 31. Neoplasia. 2019. PMID: 30591421 Free PMC article.

7

Mechanism of action and preclinical antitumor activity of the novel hypoxia-activated DNA cross-linking agent PR-104.

Patterson AV, Ferry DM, Edmunds SJ, Gu Y, Singleton RS, Patel K, Pullen SM, Hicks KO, Syddall SP, Atwell GJ, Yang S, Denny WA, Wilson WR. Patterson AV, et al. Among authors: hicks ko. Clin Cancer Res. 2007 Jul 1;13(13):3922-32. doi: 10.1158/1078-0432.CCR-07-0478. Clin Cancer Res. 2007. PMID: 17606726

8

Pharmacokinetic/pharmacodynamic model-guided identification of hypoxia-selective 1,2,4-benzotriazine 1,4-dioxides with antitumor activity: the role of extravascular transport.

Hay MP, Hicks KO, Pruijn FB, Pchalek K, Siim BG, Wilson WR, Denny WA. Hay MP, et al. Among authors: hicks ko. J Med Chem. 2007 Dec 13;50(25):6392-404. doi: 10.1021/jm070670g. Epub 2007 Nov 15. J Med Chem. 2007. PMID: 18001018

9

A combined pharmacokinetic model for the hypoxia-targeted prodrug PR-104A in humans, dogs, rats and mice predicts species differences in clearance and toxicity.

Patel K, Choy SS, Hicks KO, Melink TJ, Holford NH, Wilson WR. Patel K, et al. Among authors: hicks ko. Cancer Chemother Pharmacol. 2011 May;67(5):1145-55. doi: 10.1007/s00280-010-1412-z. Epub 2010 Aug 4. Cancer Chemother Pharmacol. 2011. PMID: 20683596

10

Pharmacokinetic/pharmacodynamic modeling identifies SN30000 and SN29751 as tirapazamine analogues with improved tissue penetration and hypoxic cell killing in tumors.

Hicks KO, Siim BG, Jaiswal JK, Pruijn FB, Fraser AM, Patel R, Hogg A, Liyanage HD, Dorie MJ, Brown JM, Denny WA, Hay MP, Wilson WR. Hicks KO, et al. Clin Cancer Res. 2010 Oct 15;16(20):4946-57. doi: 10.1158/1078-0432.CCR-10-1439. Epub 2010 Aug 20. Clin Cancer Res. 2010. PMID: 20732963 Free PMC article.

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