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Withaferin A induces heme oxygenase (HO-1) expression in endothelial cells via activation of the Keap1/Nrf2 pathway.
Heyninck K, Sabbe L, Chirumamilla CS, Szarc Vel Szic K, Vander Veken P, Lemmens KJA, Lahtela-Kakkonen M, Naulaerts S, Op de Beeck K, Laukens K, Van Camp G, Weseler AR, Bast A, Haenen GRMM, Haegeman G, Vanden Berghe W. Heyninck K, et al. Biochem Pharmacol. 2016 Jun 1;109:48-61. doi: 10.1016/j.bcp.2016.03.026. Epub 2016 Apr 1. Biochem Pharmacol. 2016. PMID: 27045103
Molecular insight in the multifunctional activities of Withaferin A.
Vanden Berghe W, Sabbe L, Kaileh M, Haegeman G, Heyninck K. Vanden Berghe W, et al. Among authors: heyninck k. Biochem Pharmacol. 2012 Nov 15;84(10):1282-91. doi: 10.1016/j.bcp.2012.08.027. Epub 2012 Sep 6. Biochem Pharmacol. 2012. PMID: 22981382 Review.
Pharmacological levels of Withaferin A (Withania somnifera) trigger clinically relevant anticancer effects specific to triple negative breast cancer cells.
Szarc vel Szic K, Op de Beeck K, Ratman D, Wouters A, Beck IM, Declerck K, Heyninck K, Fransen E, Bracke M, De Bosscher K, Lardon F, Van Camp G, Vanden Berghe W. Szarc vel Szic K, et al. Among authors: heyninck k. PLoS One. 2014 Feb 3;9(2):e87850. doi: 10.1371/journal.pone.0087850. eCollection 2014. PLoS One. 2014. PMID: 24498382 Free PMC article.
Dietary flavanols modulate the transcription of genes associated with cardiovascular pathology without changes in their DNA methylation state.
Milenkovic D, Vanden Berghe W, Boby C, Leroux C, Declerck K, Szarc vel Szic K, Heyninck K, Laukens K, Bizet M, Defrance M, Dedeurwaerder S, Calonne E, Fuks F, Haegeman G, Haenen GR, Bast A, Weseler AR. Milenkovic D, et al. Among authors: heyninck k. PLoS One. 2014 Apr 24;9(4):e95527. doi: 10.1371/journal.pone.0095527. eCollection 2014. PLoS One. 2014. PMID: 24763279 Free PMC article.
Ectopic microRNA-150-5p transcription sensitizes glucocorticoid therapy response in MM1S multiple myeloma cells but fails to overcome hormone therapy resistance in MM1R cells.
Palagani A, Op de Beeck K, Naulaerts S, Diddens J, Sekhar Chirumamilla C, Van Camp G, Laukens K, Heyninck K, Gerlo S, Mestdagh P, Vandesompele J, Berghe WV. Palagani A, et al. Among authors: heyninck k. PLoS One. 2014 Dec 4;9(12):e113842. doi: 10.1371/journal.pone.0113842. eCollection 2014. PLoS One. 2014. PMID: 25474406 Free PMC article.
Nano-targeted induction of dual ferroptotic mechanisms eradicates high-risk neuroblastoma.
Hassannia B, Wiernicki B, Ingold I, Qu F, Van Herck S, Tyurina YY, Bayır H, Abhari BA, Angeli JPF, Choi SM, Meul E, Heyninck K, Declerck K, Chirumamilla CS, Lahtela-Kakkonen M, Van Camp G, Krysko DV, Ekert PG, Fulda S, De Geest BG, Conrad M, Kagan VE, Vanden Berghe W, Vandenabeele P, Vanden Berghe T. Hassannia B, et al. Among authors: heyninck k. J Clin Invest. 2018 Aug 1;128(8):3341-3355. doi: 10.1172/JCI99032. Epub 2018 Jun 25. J Clin Invest. 2018. PMID: 29939160 Free PMC article.
47 results