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Favipiravir at high doses has potent antiviral activity in SARS-CoV-2-infected hamsters, whereas hydroxychloroquine lacks activity.
Kaptein SJF, Jacobs S, Langendries L, Seldeslachts L, Ter Horst S, Liesenborghs L, Hens B, Vergote V, Heylen E, Barthelemy K, Maas E, De Keyzer C, Bervoets L, Rymenants J, Van Buyten T, Zhang X, Abdelnabi R, Pang J, Williams R, Thibaut HJ, Dallmeier K, Boudewijns R, Wouters J, Augustijns P, Verougstraete N, Cawthorne C, Breuer J, Solas C, Weynand B, Annaert P, Spriet I, Vande Velde G, Neyts J, Rocha-Pereira J, Delang L. Kaptein SJF, et al. Among authors: heylen e. Proc Natl Acad Sci U S A. 2020 Oct 27;117(43):26955-26965. doi: 10.1073/pnas.2014441117. Epub 2020 Oct 9. Proc Natl Acad Sci U S A. 2020. PMID: 33037151 Free PMC article.
HIV protease inhibitors Nelfinavir and Lopinavir/Ritonavir markedly improve lung pathology in SARS-CoV-2-infected Syrian hamsters despite lack of an antiviral effect.
Foo CS, Abdelnabi R, Kaptein SJF, Zhang X, Ter Horst S, Mols R, Delang L, Rocha-Pereira J, Coelmont L, Leyssen P, Dallmeier K, Vergote V, Heylen E, Vangeel L, Chatterjee AK, Annaert PP, Augustijns PF, De Jonghe S, Jochmans D, Gouwy M, Cambier S, Vandooren J, Proost P, van Laer C, Weynand B, Neyts J. Foo CS, et al. Among authors: heylen e. Antiviral Res. 2022 Jun;202:105311. doi: 10.1016/j.antiviral.2022.105311. Epub 2022 Apr 4. Antiviral Res. 2022. PMID: 35390430 Free PMC article.
STAT2 signaling restricts viral dissemination but drives severe pneumonia in SARS-CoV-2 infected hamsters.
Boudewijns R, Thibaut HJ, Kaptein SJF, Li R, Vergote V, Seldeslachts L, Van Weyenbergh J, De Keyzer C, Bervoets L, Sharma S, Liesenborghs L, Ma J, Jansen S, Van Looveren D, Vercruysse T, Wang X, Jochmans D, Martens E, Roose K, De Vlieger D, Schepens B, Van Buyten T, Jacobs S, Liu Y, Martí-Carreras J, Vanmechelen B, Wawina-Bokalanga T, Delang L, Rocha-Pereira J, Coelmont L, Chiu W, Leyssen P, Heylen E, Schols D, Wang L, Close L, Matthijnssens J, Van Ranst M, Compernolle V, Schramm G, Van Laere K, Saelens X, Callewaert N, Opdenakker G, Maes P, Weynand B, Cawthorne C, Vande Velde G, Wang Z, Neyts J, Dallmeier K. Boudewijns R, et al. Among authors: heylen e. Nat Commun. 2020 Nov 17;11(1):5838. doi: 10.1038/s41467-020-19684-y. Nat Commun. 2020. PMID: 33203860 Free PMC article.
The combined treatment of Molnupiravir and Favipiravir results in a potentiation of antiviral efficacy in a SARS-CoV-2 hamster infection model.
Abdelnabi R, Foo CS, Kaptein SJF, Zhang X, Do TND, Langendries L, Vangeel L, Breuer J, Pang J, Williams R, Vergote V, Heylen E, Leyssen P, Dallmeier K, Coelmont L, Chatterjee AK, Mols R, Augustijns P, De Jonghe S, Jochmans D, Weynand B, Neyts J. Abdelnabi R, et al. Among authors: heylen e. EBioMedicine. 2021 Oct;72:103595. doi: 10.1016/j.ebiom.2021.103595. Epub 2021 Sep 24. EBioMedicine. 2021. PMID: 34571361 Free PMC article.
Reassortment of human rotavirus gene segments into G11 rotavirus strains.
Matthijnssens J, Rahman M, Ciarlet M, Zeller M, Heylen E, Nakagomi T, Uchida R, Hassan Z, Azim T, Nakagomi O, Van Ranst M. Matthijnssens J, et al. Among authors: heylen e. Emerg Infect Dis. 2010 Apr;16(4):625-30. doi: 10.3201/eid1604.091591. Emerg Infect Dis. 2010. PMID: 20350376 Free PMC article.
Characterization of a genetically heterogeneous porcine rotavirus C, and other viruses present in the fecal virome of a non-diarrheic Belgian piglet.
Theuns S, Conceição-Neto N, Zeller M, Heylen E, Roukaerts ID, Desmarets LM, Van Ranst M, Nauwynck HJ, Matthijnssens J. Theuns S, et al. Among authors: heylen e. Infect Genet Evol. 2016 Sep;43:135-45. doi: 10.1016/j.meegid.2016.05.018. Epub 2016 May 14. Infect Genet Evol. 2016. PMID: 27184192 Free PMC article.
151 results