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Synthesis and SAR of novel GPR39 agonists and positive allosteric modulators.
Bioorg Med Chem Lett. 2022 Apr 1;61:128607. doi: 10.1016/j.bmcl.2022.128607. Epub 2022 Feb 3.
Bioorg Med Chem Lett. 2022.
PMID: 35123006
Discovery and Characterization of Novel CNS-Penetrant GPR55 Agonists.
Hewer RC, Christie LA, Doyle KJ, Xu X, Roberts MJ, Dickson L, Cheung T, Cadwalladr DH, Pickford P, Teall M, Powell JAC, Sheardown S, Narayana L, Brice NL, Dawson LA, Carlton M, Bürli RW.
Hewer RC, et al.
J Med Chem. 2023 Sep 28;66(18):12858-12876. doi: 10.1021/acs.jmedchem.3c00784. Epub 2023 Sep 14.
J Med Chem. 2023.
PMID: 37708305
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Inhibition of Egr1 expression underlies the anti-mitogenic effects of cAMP in vascular smooth muscle cells.
Kimura TE, Duggirala A, Hindmarch CC, Hewer RC, Cui MZ, Newby AC, Bond M.
Kimura TE, et al. Among authors: hewer rc.
J Mol Cell Cardiol. 2014 Jul;72(100):9-19. doi: 10.1016/j.yjmcc.2014.02.001. Epub 2014 Feb 15.
J Mol Cell Cardiol. 2014.
PMID: 24534707
Free PMC article.
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PKA and Epac synergistically inhibit smooth muscle cell proliferation.
Hewer RC, Sala-Newby GB, Wu YJ, Newby AC, Bond M.
Hewer RC, et al.
J Mol Cell Cardiol. 2011 Jan;50(1):87-98. doi: 10.1016/j.yjmcc.2010.10.010. Epub 2010 Oct 30.
J Mol Cell Cardiol. 2011.
PMID: 20971121
Free PMC article.
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