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Page 1
GPVI expression is linked to platelet size, age, and reactivity.
Veninga A, Handtke S, Aurich K, Tullemans BME, Brouns SLN, Schwarz SL, Heubel-Moenen FCJI, Greinacher A, Heemskerk JWM, van der Meijden PEJ, Thiele T. Veninga A, et al. Blood Adv. 2022 Jul 26;6(14):4162-4173. doi: 10.1182/bloodadvances.2021006904. Blood Adv. 2022. PMID: 35561312 Free PMC article.
Nonredundant Roles of Platelet Glycoprotein VI and Integrin αIIbβ3 in Fibrin-Mediated Microthrombus Formation.
Perrella G, Huang J, Provenzale I, Swieringa F, Heubel-Moenen FCJI, Farndale RW, Roest M, van der Meijden PEJ, Thomas M, Ariëns RAS, Jandrot-Perrus M, Watson SP, Heemskerk JWM. Perrella G, et al. Arterioscler Thromb Vasc Biol. 2021 Feb;41(2):e97-e111. doi: 10.1161/ATVBAHA.120.314641. Epub 2020 Dec 3. Arterioscler Thromb Vasc Biol. 2021. PMID: 33267658 Free article.
Is pharmacokinetic-guided dosing of desmopressin and von Willebrand factor-containing concentrates in individuals with von Willebrand disease or low von Willebrand factor reliable and feasible? A protocol for a multicentre, non-randomised, open label cohort trial, the OPTI-CLOT: to WiN study.
Heijdra JM, Al Arashi W, de Jager NCB, Cloesmeijer ME, Bukkems LH, Zwaan CM, Leebeek FWG, Mathôt RAA, Cnossen MH; OPTI-CLOT Study Group. Heijdra JM, et al. BMJ Open. 2022 Feb 15;12(2):e049493. doi: 10.1136/bmjopen-2021-049493. BMJ Open. 2022. PMID: 35168962 Free PMC article.
Perioperative pharmacokinetic-guided factor VIII concentrate dosing in haemophilia (OPTI-CLOT trial): an open-label, multicentre, randomised, controlled trial.
van Moort I, Preijers T, Bukkems LH, Hazendonk HCAM, van der Bom JG, Laros-van Gorkom BAP, Beckers EAM, Nieuwenhuizen L, van der Meer FJM, Ypma P, Coppens M, Fijnvandraat K, Schutgens REG, Meijer K, Leebeek FWG, Mathôt RAA, Cnossen MH; OPTI-CLOT study group. van Moort I, et al. Lancet Haematol. 2021 Jul;8(7):e492-e502. doi: 10.1016/S2352-3026(21)00135-6. Lancet Haematol. 2021. PMID: 34171280 Clinical Trial.
Design of a Prospective Study on Pharmacokinetic-Guided Dosing of Prophylactic Factor Replacement in Hemophilia A and B (OPTI-CLOT TARGET Study).
Goedhart TMHJ, Bukkems LH, Coppens M, Fijnvandraat KJ, Schols SEM, Schutgens REG, Eikenboom J, Heubel-Moenen FCJI, Ypma PF, Nieuwenhuizen L, Meijer K, Leebeek FWG, Mathôt RAA, Cnossen MH. Goedhart TMHJ, et al. TH Open. 2022 Feb 3;6(1):e60-e69. doi: 10.1055/a-1760-0105. eCollection 2022 Jan. TH Open. 2022. PMID: 35280975 Free PMC article.
Desmopressin testing in von Willebrand disease: Lowering the burden.
Heijdra JM, Atiq F, Al Arashi W, Kieboom Q, Wuijster E, Meijer K, Kruip MJHA, Leebeek FWG, Cnossen MH; OPTI‐CLOT Study Group. Heijdra JM, et al. Res Pract Thromb Haemost. 2022 Sep 26;6(6):e12784. doi: 10.1002/rth2.12784. eCollection 2022 Aug. Res Pract Thromb Haemost. 2022. PMID: 36186107 Free PMC article.
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