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Caspase-1-driven neutrophil pyroptosis and its role in host susceptibility to Pseudomonas aeruginosa.
Santoni K, Pericat D, Gorse L, Buyck J, Pinilla M, Prouvensier L, Bagayoko S, Hessel A, Leon-Icaza SA, Bellard E, Mazères S, Doz-Deblauwe E, Winter N, Paget C, Girard JP, Pham CTN, Cougoule C, Poincloux R, Lamkanfi M, Lefrançais E, Meunier E, Planès R. Santoni K, et al. Among authors: hessel a. PLoS Pathog. 2022 Jul 18;18(7):e1010305. doi: 10.1371/journal.ppat.1010305. eCollection 2022 Jul. PLoS Pathog. 2022. PMID: 35849616 Free PMC article.
Irgm2 and Gate-16 cooperatively dampen Gram-negative bacteria-induced caspase-11 response.
Eren E, Planès R, Bagayoko S, Bordignon PJ, Chaoui K, Hessel A, Santoni K, Pinilla M, Lagrange B, Burlet-Schiltz O, Howard JC, Henry T, Yamamoto M, Meunier E. Eren E, et al. Among authors: hessel a. EMBO Rep. 2020 Nov 5;21(11):e50829. doi: 10.15252/embr.202050829. Epub 2020 Oct 30. EMBO Rep. 2020. PMID: 33124769 Free PMC article.
Host phospholipid peroxidation fuels ExoU-dependent cell necrosis and supports Pseudomonas aeruginosa-driven pathology.
Bagayoko S, Leon-Icaza SA, Pinilla M, Hessel A, Santoni K, Péricat D, Bordignon PJ, Moreau F, Eren E, Boyancé A, Naser E, Lefèvre L, Berrone C, Iakobachvili N, Metais A, Rombouts Y, Lugo-Villarino G, Coste A, Attrée I, Frank DW, Clevers H, Peters PJ, Cougoule C, Planès R, Meunier E. Bagayoko S, et al. Among authors: hessel a. PLoS Pathog. 2021 Sep 13;17(9):e1009927. doi: 10.1371/journal.ppat.1009927. eCollection 2021 Sep. PLoS Pathog. 2021. PMID: 34516571 Free PMC article.
Human NLRP1 is a sensor of pathogenic coronavirus 3CL proteases in lung epithelial cells.
Planès R, Pinilla M, Santoni K, Hessel A, Passemar C, Lay K, Paillette P, Valadão AC, Robinson KS, Bastard P, Lam N, Fadrique R, Rossi I, Pericat D, Bagayoko S, Leon-Icaza SA, Rombouts Y, Perouzel E, Tiraby M; COVID Human Genetic Effort; Zhang Q, Cicuta P, Jouanguy E, Neyrolles O, Bryant CE, Floto AR, Goujon C, Lei FZ, Martin-Blondel G, Silva S, Casanova JL, Cougoule C, Reversade B, Marcoux J, Ravet E, Meunier E. Planès R, et al. Among authors: hessel a. Mol Cell. 2022 Jul 7;82(13):2385-2400.e9. doi: 10.1016/j.molcel.2022.04.033. Epub 2022 May 16. Mol Cell. 2022. PMID: 35594856 Free PMC article.
EEF2-inactivating toxins engage the NLRP1 inflammasome and promote epithelial barrier disruption.
Pinilla M, Mazars R, Vergé R, Gorse L, Paradis M, Suire B, Santoni K, Robinson KS, Toh GA, Prouvensier L, Leon-Icaza SA, Hessel A, Péricat D, Murris M, Guet-Revillet H, Henras A, Buyck J, Ravet E, Zhong FL, Cougoule C, Planès R, Meunier E. Pinilla M, et al. Among authors: hessel a. J Exp Med. 2023 Oct 2;220(10):e20230104. doi: 10.1084/jem.20230104. Epub 2023 Aug 29. J Exp Med. 2023. PMID: 37642996 Free PMC article.
Characterization of a membrane-active peptide from the Bordetella pertussis CyaA toxin.
Subrini O, Sotomayor-Pérez AC, Hessel A, Spiaczka-Karst J, Selwa E, Sapay N, Veneziano R, Pansieri J, Chopineau J, Ladant D, Chenal A. Subrini O, et al. Among authors: hessel a. J Biol Chem. 2013 Nov 8;288(45):32585-32598. doi: 10.1074/jbc.M113.508838. Epub 2013 Sep 24. J Biol Chem. 2013. PMID: 24064217 Free PMC article.
Calcium-dependent disorder-to-order transitions are central to the secretion and folding of the CyaA toxin of Bordetella pertussis, the causative agent of whooping cough.
O'Brien DP, Perez ACS, Karst J, Cannella SE, Enguéné VYN, Hessel A, Raoux-Barbot D, Voegele A, Subrini O, Davi M, Guijarro JI, Raynal B, Baron B, England P, Hernandez B, Ghomi M, Hourdel V, Malosse C, Chamot-Rooke J, Vachette P, Durand D, Brier S, Ladant D, Chenal A. O'Brien DP, et al. Among authors: hessel a. Toxicon. 2018 Jul;149:37-44. doi: 10.1016/j.toxicon.2018.01.007. Epub 2018 Jan 12. Toxicon. 2018. PMID: 29337218 Review.
163 results