Herzyk DJ - Search Results

1

An Evaluation of the Impact of PD-1 Pathway Blockade on Reproductive Safety of Therapeutic PD-1 Inhibitors.

Poulet FM, Wolf JJ, Herzyk DJ, DeGeorge JJ. Poulet FM, et al. Among authors: herzyk dj. Birth Defects Res B Dev Reprod Toxicol. 2016 Apr;107(2):108-19. doi: 10.1002/bdrb.21176. Epub 2016 Apr 7. Birth Defects Res B Dev Reprod Toxicol. 2016. PMID: 27062127 Review.

2

Biophysical and Immunological Characterization and In Vivo Pharmacokinetics and Toxicology in Nonhuman Primates of the Anti-PD-1 Antibody Pembrolizumab.

Hutchins B, Starling GC, McCoy MA, Herzyk D, Poulet FM, Dulos J, Liu L, Kang SP, Fayadat-Dilman L, Hsieh M, Andrews CL, Ayanoglu G, Cullen C, Malefyt RW, Kastelein RA, Saux SL, Lee J, Li S, Malashock D, Sadekova S, Soder G, van Eenennaam H, Willingham A, Yu Y, Streuli M, Carven GJ, van Elsas A. Hutchins B, et al. Mol Cancer Ther. 2020 Jun;19(6):1298-1307. doi: 10.1158/1535-7163.MCT-19-0774. Epub 2020 Mar 30. Mol Cancer Ther. 2020. PMID: 32229606

3

Nonclinical safety of tildrakizumab, a humanized anti-IL-23p19 monoclonal antibody, in nonhuman primates.

Santostefano M, Herzyk D, Montgomery D, Wolf J. Santostefano M, et al. Regul Toxicol Pharmacol. 2019 Nov;108:104476. doi: 10.1016/j.yrtph.2019.104476. Epub 2019 Sep 16. Regul Toxicol Pharmacol. 2019. PMID: 31536773

4

Cancer Immunotherapy: Factors Important for the Evaluation of Safety in Nonclinical Studies.

Herzyk DJ, Haggerty HG. Herzyk DJ, et al. AAPS J. 2018 Feb 7;20(2):28. doi: 10.1208/s12248-017-0184-3. AAPS J. 2018. PMID: 29417397 Review.

5

A T-cell-dependent antibody response study using a murine surrogate anti-PD-1 monoclonal antibody as an alternative to a non-human primate model.

Plitnick LM, Hutchins B, Dubey S, Li N, Amin RP, Born S, Mangadu R, Phillips JH, Sriram V, Herzyk DJ. Plitnick LM, et al. Among authors: herzyk dj. J Immunotoxicol. 2020 Dec;17(1):175-185. doi: 10.1080/1547691X.2020.1826020. J Immunotoxicol. 2020. PMID: 33078980

6

Drug safety Africa: An overview of safety pharmacology & toxicology in South Africa.

Guth BD, Grobler AF, Frazier KS, Greiter-Wilke A, Herzyk D, Hough TA, Khan AA, Markert M, Smith JD, Svenson KL, Wells S, Pugsley MK. Guth BD, et al. J Pharmacol Toxicol Methods. 2019 Jul-Aug;98:106579. doi: 10.1016/j.vascn.2019.106579. Epub 2019 May 11. J Pharmacol Toxicol Methods. 2019. PMID: 31085319 Free article. Review.

7

HESI/FDA workshop on immunomodulators and cancer risk assessment: Building blocks for a weight-of-evidence approach.

Lebrec H, Brennan FR, Haggerty H, Herzyk D, Kamperschroer C, Maier CC, Ponce R, Preston BD, Weinstock D, Mellon RD. Lebrec H, et al. Regul Toxicol Pharmacol. 2016 Mar;75:72-80. doi: 10.1016/j.yrtph.2015.12.018. Epub 2015 Dec 29. Regul Toxicol Pharmacol. 2016. PMID: 26743742 Free article.

8

Industry experiences with immune-mediated findings in biotherapeutic nonclinical toxicology studies.

MacLachlan TK, Kronenberg S, Marshall N, Andrews L, Berens SJ, Brouta F, Fogal B, Freebern W, Herzyk D, Kamperschroer C, Kiessling A, Schneidkraut M, Maier C. MacLachlan TK, et al. Regul Toxicol Pharmacol. 2021 Feb;119:104825. doi: 10.1016/j.yrtph.2020.104825. Epub 2020 Nov 19. Regul Toxicol Pharmacol. 2021. PMID: 33220389

9

Characterization of MK-4166, a Clinical Agonistic Antibody That Targets Human GITR and Inhibits the Generation and Suppressive Effects of T Regulatory Cells.

Sukumar S, Wilson DC, Yu Y, Wong J, Naravula S, Ermakov G, Riener R, Bhagwat B, Necheva AS, Grein J, Churakova T, Mangadu R, Georgiev P, Manfra D, Pinheiro EM, Sriram V, Bailey WJ, Herzyk D, McClanahan TK, Willingham A, Beebe AM, Sadekova S. Sukumar S, et al. Cancer Res. 2017 Aug 15;77(16):4378-4388. doi: 10.1158/0008-5472.CAN-16-1439. Epub 2017 Jun 13. Cancer Res. 2017. PMID: 28611044

10

Preclinical efficacy and safety of mepolizumab (SB-240563), a humanized monoclonal antibody to IL-5, in cynomolgus monkeys.

Hart TK, Cook RM, Zia-Amirhosseini P, Minthorn E, Sellers TS, Maleeff BE, Eustis S, Schwartz LW, Tsui P, Appelbaum ER, Martin EC, Bugelski PJ, Herzyk DJ. Hart TK, et al. Among authors: herzyk dj. J Allergy Clin Immunol. 2001 Aug;108(2):250-7. doi: 10.1067/mai.2001.116576. J Allergy Clin Immunol. 2001. PMID: 11496242

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