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The interplay between BAX and BAK tunes apoptotic pore growth to control mitochondrial-DNA-mediated inflammation.
Mol Cell. 2022 Mar 3;82(5):933-949.e9. doi: 10.1016/j.molcel.2022.01.008. Epub 2022 Feb 3.
Mol Cell. 2022.
PMID: 35120587
Free PMC article.
BCL-2-family protein tBID can act as a BAX-like effector of apoptosis.
Flores-Romero H, Hohorst L, John M, Albert MC, King LE, Beckmann L, Szabo T, Hertlein V, Luo X, Villunger A, Frenzel LP, Kashkar H, Garcia-Saez AJ.
Flores-Romero H, et al. Among authors: hertlein v.
EMBO J. 2022 Dec 17;41(2):e108690. doi: 10.15252/embj.2021108690. Epub 2021 Dec 21.
EMBO J. 2022.
PMID: 34931711
Free PMC article.
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MERLIN: a novel BRET-based proximity biosensor for studying mitochondria-ER contact sites.
Hertlein V, Flores-Romero H, Das KK, Fischer S, Heunemann M, Calleja-Felipe M, Knafo S, Hipp K, Harter K, Fitzgerald JC, García-Sáez AJ.
Hertlein V, et al.
Life Sci Alliance. 2019 Dec 9;3(1):e201900600. doi: 10.26508/lsa.201900600. Print 2020 Jan.
Life Sci Alliance. 2019.
PMID: 31818884
Free PMC article.
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Biallelic NFATC1 mutations cause an inborn error of immunity with impaired CD8+ T-cell function and perturbed glycolysis.
Kostel Bal S, Giuliani S, Block J, Repiscak P, Hafemeister C, Shahin T, Kasap N, Ransmayr B, Miao Y, van de Wetering C, Frohne A, Jimenez Heredia R, Schuster M, Zoghi S, Hertlein V, Thian M, Bykov A, Babayeva R, Bilgic Eltan S, Karakoc-Aydiner E, Shaw LE, Chowdhury I, Varjosalo M, Argüello RJ, Farlik M, Ozen A, Serfling E, Dupré L, Bock C, Halbritter F, Hannich JT, Castanon I, Kraakman MJ, Baris S, Boztug K.
Kostel Bal S, et al. Among authors: hertlein v.
Blood. 2023 Aug 31;142(9):827-845. doi: 10.1182/blood.2022018303.
Blood. 2023.
PMID: 37249233
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Visualization of BOK pores independent of BAX and BAK reveals a similar mechanism with differing regulation.
Shalaby R, Diwan A, Flores-Romero H, Hertlein V, Garcia-Saez AJ.
Shalaby R, et al. Among authors: hertlein v.
Cell Death Differ. 2023 Mar;30(3):731-741. doi: 10.1038/s41418-022-01078-w. Epub 2022 Oct 26.
Cell Death Differ. 2023.
PMID: 36289446
Free PMC article.
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