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Graft dysfunction in compassionate use of genetically engineered pig-to-human cardiac xenotransplantation: a case report.
Mohiuddin MM, Singh AK, Scobie L, Goerlich CE, Grazioli A, Saharia K, Crossan C, Burke A, Drachenberg C, Oguz C, Zhang T, Lewis B, Hershfeld A, Sentz F, Tatarov I, Mudd S, Braileanu G, Rice K, Paolini JF, Bondensgaard K, Vaught T, Kuravi K, Sorrells L, Dandro A, Ayares D, Lau C, Griffith BP. Mohiuddin MM, et al. Among authors: hershfeld a. Lancet. 2023 Jul 29;402(10399):397-410. doi: 10.1016/S0140-6736(23)00775-4. Epub 2023 Jun 29. Lancet. 2023. PMID: 37393920
Blood Cardioplegia Induction, Perfusion Storage and Graft Dysfunction in Cardiac Xenotransplantation.
Goerlich CE, Griffith B, Singh AK, Abdullah M, Singireddy S, Kolesnik I, Lewis B, Sentz F, Tatarov I, Hershfeld A, Zhang T, Strauss E, Odonkor P, Williams B, Tabatabai A, Bhutta A, Ayares D, Kaczorowski DJ, Mohiuddin MM. Goerlich CE, et al. Among authors: hershfeld a. Front Immunol. 2021 Jun 9;12:667093. doi: 10.3389/fimmu.2021.667093. eCollection 2021. Front Immunol. 2021. PMID: 34177906 Free PMC article.
Progressive genetic modifications of porcine cardiac xenografts extend survival to 9 months.
Mohiuddin MM, Goerlich CE, Singh AK, Zhang T, Tatarov I, Lewis B, Sentz F, Hershfeld A, Braileanu G, Odonkor P, Strauss E, Williams B, Burke A, Hittman J, Bhutta A, Tabatabai A, Gupta A, Vaught T, Sorrells L, Kuravi K, Dandro A, Eyestone W, Kaczorowski DJ, Ayares D, Griffith BP. Mohiuddin MM, et al. Among authors: hershfeld a. Xenotransplantation. 2022 May;29(3):e12744. doi: 10.1111/xen.12744. Epub 2022 Mar 31. Xenotransplantation. 2022. PMID: 35357044 Free PMC article.
N-glycolylneuraminic acid knockout reduces erythrocyte sequestration and thromboxane elaboration in an ex vivo pig-to-human xenoperfusion model.
Cimeno A, Hassanein W, French BM, Powell JM, Burdorf L, Goloubeva O, Cheng X, Parsell DM, Ramsoondar J, Kuravi K, Vaught T, Uluer MC, Redding E, O'Neill N, Laird C, Hershfeld A, Tatarov I, Thomas K, Ayares D, Azimzadeh AM, Pierson RN 3rd, Barth RN, LaMattina JC. Cimeno A, et al. Among authors: hershfeld a. Xenotransplantation. 2017 Nov;24(6):10.1111/xen.12339. doi: 10.1111/xen.12339. Epub 2017 Sep 22. Xenotransplantation. 2017. PMID: 28940313 Free PMC article.
Comparative Evaluation of αCD40 (2C10R4) and αCD154 (5C8H1 and IDEC-131) in a Nonhuman Primate Cardiac Allotransplant Model.
OʼNeill NA, Zhang T, Braileanu G, Sun W, Cheng X, Hershfeld A, Laird CT, Kronfli A, Hock LA, Dahi S, Kubicki N, Sievert E, Hassanein W, Cimeno A, Pierson RN 3rd, Azimzadeh AM. OʼNeill NA, et al. Among authors: hershfeld a. Transplantation. 2017 Sep;101(9):2038-2047. doi: 10.1097/TP.0000000000001836. Transplantation. 2017. PMID: 28557955 Free PMC article.
Pilot Study of Delayed ICOS/ICOS-L Blockade With αCD40 to Modulate Pathogenic Alloimmunity in a Primate Cardiac Allograft Model.
O'Neill NA, Zhang T, Braileanu G, Cheng X, Hershfeld A, Sun W, Reimann KA, Dahi S, Kubicki N, Hassanein W, Laird C, Cimeno A, Azimzadeh AM, Pierson RN. O'Neill NA, et al. Among authors: hershfeld a. Transplant Direct. 2018 Feb 2;4(2):e344. doi: 10.1097/TXD.0000000000000761. eCollection 2018 Feb. Transplant Direct. 2018. PMID: 29464205 Free PMC article.
Preemptive CD20+ B cell Depletion Attenuates Cardiac Allograft Vasculopathy in CD154-Treated Monkeys.
Azimzadeh AM, Zhang T, Wu G, Kelishadi SS, Stoddard T, OʼNeill N, Nguyen BN, Welty E, Avon C, Higuchi M, Mitchell SL, Hershfeld A, Cheng XF, Kronfli A, Rybak E, Burdorf L, Pierson RN 3rd. Azimzadeh AM, et al. Among authors: hershfeld a. Transplantation. 2017 Jan;101(1):63-73. doi: 10.1097/TP.0000000000001258. Transplantation. 2017. PMID: 27362307 Free PMC article.
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