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Caveolin-1 is down-regulated in alveolar rhabdomyosarcomas and negatively regulates tumor growth.
Huertas-Martínez J, Rello-Varona S, Herrero-Martín D, Barrau I, García-Monclús S, Sáinz-Jaspeado M, Lagares-Tena L, Núñez-Álvarez Y, Mateo-Lozano S, Mora J, Roma J, Toran N, Moran S, López-Alemany R, Gallego S, Esteller M, Peinado MA, Del Muro XG, Tirado OM. Huertas-Martínez J, et al. Oncotarget. 2014 Oct 30;5(20):9744-55. doi: 10.18632/oncotarget.2403. Oncotarget. 2014. PMID: 25313138 Free PMC article.
Caveolin-1 promotes Ewing sarcoma metastasis regulating MMP-9 expression through MAPK/ERK pathway.
Lagares-Tena L, García-Monclús S, López-Alemany R, Almacellas-Rabaiget O, Huertas-Martínez J, Sáinz-Jaspeado M, Mateo-Lozano S, Rodríguez-Galindo C, Rello-Varona S, Herrero-Martín D, Tirado OM. Lagares-Tena L, et al. Among authors: herrero martin d. Oncotarget. 2016 Aug 30;7(35):56889-56903. doi: 10.18632/oncotarget.10872. Oncotarget. 2016. PMID: 27487136 Free PMC article.
DNA methylation profiling identifies PTRF/Cavin-1 as a novel tumor suppressor in Ewing sarcoma when co-expressed with caveolin-1.
Huertas-Martínez J, Court F, Rello-Varona S, Herrero-Martín D, Almacellas-Rabaiget O, Sáinz-Jaspeado M, Garcia-Monclús S, Lagares-Tena L, Buj R, Hontecillas-Prieto L, Sastre A, Azorin D, Sanjuan X, López-Alemany R, Moran S, Roma J, Gallego S, Mora J, García Del Muro X, Giangrande PH, Peinado MA, Alonso J, de Alava E, Monk D, Esteller M, Tirado OM. Huertas-Martínez J, et al. Among authors: herrero martin d. Cancer Lett. 2017 Feb 1;386:196-207. doi: 10.1016/j.canlet.2016.11.020. Epub 2016 Nov 25. Cancer Lett. 2017. PMID: 27894957
LOXL2 promotes oncogenic progression in alveolar rhabdomyosarcoma independently of its catalytic activity.
Almacellas-Rabaiget O, Monaco P, Huertas-Martinez J, García-Monclús S, Chicón-Bosch M, Maqueda-Marcos S, Fabra-Heredia I, Herrero-Martín D, Rello-Varona S, de Alava E, López-Alemany R, Giangrande PH, Tirado OM. Almacellas-Rabaiget O, et al. Among authors: herrero martin d. Cancer Lett. 2020 Apr 1;474:1-14. doi: 10.1016/j.canlet.2019.12.040. Epub 2020 Jan 3. Cancer Lett. 2020. PMID: 31911079
The PARP inhibitor olaparib enhances the sensitivity of Ewing sarcoma to trabectedin.
Ordóñez JL, Amaral AT, Carcaboso AM, Herrero-Martín D, del Carmen García-Macías M, Sevillano V, Alonso D, Pascual-Pasto G, San-Segundo L, Vila-Ubach M, Rodrigues T, Fraile S, Teodosio C, Mayo-Iscar A, Aracil M, Galmarini CM, Tirado OM, Mora J, de Álava E. Ordóñez JL, et al. Among authors: herrero martin d. Oncotarget. 2015 Aug 7;6(22):18875-90. doi: 10.18632/oncotarget.4303. Oncotarget. 2015. PMID: 26056084 Free PMC article.
EphA2 receptor is a key player in the metastatic onset of Ewing sarcoma.
Garcia-Monclús S, López-Alemany R, Almacellas-Rabaiget O, Herrero-Martín D, Huertas-Martinez J, Lagares-Tena L, Alba-Pavón P, Hontecillas-Prieto L, Mora J, de Álava E, Rello-Varona S, Giangrande PH, Tirado OM. Garcia-Monclús S, et al. Among authors: herrero martin d. Int J Cancer. 2018 Sep 1;143(5):1188-1201. doi: 10.1002/ijc.31405. Epub 2018 Apr 16. Int J Cancer. 2018. PMID: 29582409 Free PMC article.
Cell Death Identification in Anticancer Therapy-Response.
Rello-Varona S, Herrero-Martín D, López-Alemany R, Tirado OM. Rello-Varona S, et al. Among authors: herrero martin d. Cancer Res. 2015 Sep 1;75(17):3682. doi: 10.1158/0008-5472.CAN-15-1540. Epub 2015 Aug 18. Cancer Res. 2015. PMID: 26286475 No abstract available.
The transcribed pseudogene RPSAP52 enhances the oncofetal HMGA2-IGF2BP2-RAS axis through LIN28B-dependent and independent let-7 inhibition.
Oliveira-Mateos C, Sánchez-Castillo A, Soler M, Obiols-Guardia A, Piñeyro D, Boque-Sastre R, Calleja-Cervantes ME, Castro de Moura M, Martínez-Cardús A, Rubio T, Pelletier J, Martínez-Iniesta M, Herrero-Martín D, Tirado OM, Gentilella A, Villanueva A, Esteller M, Farré L, Guil S. Oliveira-Mateos C, et al. Among authors: herrero martin d. Nat Commun. 2019 Sep 4;10(1):3979. doi: 10.1038/s41467-019-11910-6. Nat Commun. 2019. PMID: 31484926 Free PMC article.
The importance of being dead: cell death mechanisms assessment in anti-sarcoma therapy.
Rello-Varona S, Herrero-Martín D, Lagares-Tena L, López-Alemany R, Mulet-Margalef N, Huertas-Martínez J, Garcia-Monclús S, García Del Muro X, Muñoz-Pinedo C, Tirado OM. Rello-Varona S, et al. Front Oncol. 2015 Apr 7;5:82. doi: 10.3389/fonc.2015.00082. eCollection 2015. Front Oncol. 2015. PMID: 25905041 Free PMC article. Review.
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