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An epigenetic switch controls an alternative NR2F2 isoform that unleashes a metastatic program in melanoma.
Davalos V, Lovell CD, Von Itter R, Dolgalev I, Agrawal P, Baptiste G, Kahler DJ, Sokolova E, Moran S, Piqué L, Vega-Saenz de Miera E, Fontanals-Cirera B, Karz A, Tsirigos A, Yun C, Darvishian F, Etchevers HC, Osman I, Esteller M, Schober M, Hernando E. Davalos V, et al. Among authors: hernando e. Nat Commun. 2023 Apr 4;14(1):1867. doi: 10.1038/s41467-023-36967-2. Nat Commun. 2023. PMID: 37015919 Free PMC article.
Aberrant miR-182 expression promotes melanoma metastasis by repressing FOXO3 and microphthalmia-associated transcription factor.
Segura MF, Hanniford D, Menendez S, Reavie L, Zou X, Alvarez-Diaz S, Zakrzewski J, Blochin E, Rose A, Bogunovic D, Polsky D, Wei J, Lee P, Belitskaya-Levy I, Bhardwaj N, Osman I, Hernando E. Segura MF, et al. Among authors: hernando e. Proc Natl Acad Sci U S A. 2009 Feb 10;106(6):1814-9. doi: 10.1073/pnas.0808263106. Epub 2009 Feb 2. Proc Natl Acad Sci U S A. 2009. PMID: 19188590 Free PMC article.
Melanoma MicroRNA signature predicts post-recurrence survival.
Segura MF, Belitskaya-Lévy I, Rose AE, Zakrzewski J, Gaziel A, Hanniford D, Darvishian F, Berman RS, Shapiro RL, Pavlick AC, Osman I, Hernando E. Segura MF, et al. Among authors: hernando e. Clin Cancer Res. 2010 Mar 1;16(5):1577-86. doi: 10.1158/1078-0432.CCR-09-2721. Epub 2010 Feb 23. Clin Cancer Res. 2010. PMID: 20179230 Free PMC article.
Clinical relevance of SKP2 alterations in metastatic melanoma.
Rose AE, Wang G, Hanniford D, Monni S, Tu T, Shapiro RL, Berman RS, Pavlick AC, Pagano M, Darvishian F, Mazumdar M, Hernando E, Osman I. Rose AE, et al. Among authors: hernando e. Pigment Cell Melanoma Res. 2011 Feb;24(1):197-206. doi: 10.1111/j.1755-148X.2010.00784.x. Epub 2010 Oct 21. Pigment Cell Melanoma Res. 2011. PMID: 20883453 Free PMC article.
Efficient in vivo microRNA targeting of liver metastasis.
Huynh C, Segura MF, Gaziel-Sovran A, Menendez S, Darvishian F, Chiriboga L, Levin B, Meruelo D, Osman I, Zavadil J, Marcusson EG, Hernando E. Huynh C, et al. Among authors: hernando e. Oncogene. 2011 Mar 24;30(12):1481-8. doi: 10.1038/onc.2010.523. Epub 2010 Nov 22. Oncogene. 2011. PMID: 21102518
The histone variant macroH2A suppresses melanoma progression through regulation of CDK8.
Kapoor A, Goldberg MS, Cumberland LK, Ratnakumar K, Segura MF, Emanuel PO, Menendez S, Vardabasso C, Leroy G, Vidal CI, Polsky D, Osman I, Garcia BA, Hernando E, Bernstein E. Kapoor A, et al. Among authors: hernando e. Nature. 2010 Dec 23;468(7327):1105-9. doi: 10.1038/nature09590. Nature. 2010. PMID: 21179167 Free PMC article.
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