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Interplay between glutamatergic and GABAergic neurotransmission alterations in cognitive and motor impairment in minimal hepatic encephalopathy.
Llansola M, Montoliu C, Agusti A, Hernandez-Rabaza V, Cabrera-Pastor A, Gomez-Gimenez B, Malaguarnera M, Dadsetan S, Belghiti M, Garcia-Garcia R, Balzano T, Taoro L, Felipo V. Llansola M, et al. Neurochem Int. 2015 Sep;88:15-9. doi: 10.1016/j.neuint.2014.10.011. Epub 2014 Nov 20. Neurochem Int. 2015. PMID: 25447766 Review.
Neuroinflammation increases GABAergic tone and impairs cognitive and motor function in hyperammonemia by increasing GAT-3 membrane expression. Reversal by sulforaphane by promoting M2 polarization of microglia.
Hernandez-Rabaza V, Cabrera-Pastor A, Taoro-Gonzalez L, Gonzalez-Usano A, Agusti A, Balzano T, Llansola M, Felipo V. Hernandez-Rabaza V, et al. J Neuroinflammation. 2016 Apr 18;13(1):83. doi: 10.1186/s12974-016-0549-z. J Neuroinflammation. 2016. PMID: 27090509 Free PMC article.
Infliximab reduces peripheral inflammation, neuroinflammation, and extracellular GABA in the cerebellum and improves learning and motor coordination in rats with hepatic encephalopathy.
Dadsetan S, Balzano T, Forteza J, Agusti A, Cabrera-Pastor A, Taoro-Gonzalez L, Hernandez-Rabaza V, Gomez-Gimenez B, ElMlili N, Llansola M, Felipo V. Dadsetan S, et al. J Neuroinflammation. 2016 Sep 13;13(1):245. doi: 10.1186/s12974-016-0710-8. J Neuroinflammation. 2016. PMID: 27623772 Free PMC article.
38 results