Herlyn M - Search Results

1

Pathway signatures derived from on-treatment tumor specimens predict response to anti-PD1 blockade in metastatic melanoma.

Du K, Wei S, Wei Z, Frederick DT, Miao B, Moll T, Tian T, Sugarman E, Gabrilovich DI, Sullivan RJ, Liu L, Flaherty KT, Boland GM, Herlyn M, Zhang G. Du K, et al. Among authors: herlyn m. Nat Commun. 2021 Oct 15;12(1):6023. doi: 10.1038/s41467-021-26299-4. Nat Commun. 2021. PMID: 34654806 Free PMC article.

2

Multiple signaling pathways must be targeted to overcome drug resistance in cell lines derived from melanoma metastases.

Smalley KS, Haass NK, Brafford PA, Lioni M, Flaherty KT, Herlyn M. Smalley KS, et al. Among authors: herlyn m. Mol Cancer Ther. 2006 May;5(5):1136-44. doi: 10.1158/1535-7163.MCT-06-0084. Mol Cancer Ther. 2006. PMID: 16731745

3

An organometallic protein kinase inhibitor pharmacologically activates p53 and induces apoptosis in human melanoma cells.

Smalley KS, Contractor R, Haass NK, Kulp AN, Atilla-Gokcumen GE, Williams DS, Bregman H, Flaherty KT, Soengas MS, Meggers E, Herlyn M. Smalley KS, et al. Among authors: herlyn m. Cancer Res. 2007 Jan 1;67(1):209-17. doi: 10.1158/0008-5472.CAN-06-1538. Cancer Res. 2007. PMID: 17210701

4

Ki67 expression levels are a better marker of reduced melanoma growth following MEK inhibitor treatment than phospho-ERK levels.

Smalley KS, Contractor R, Haass NK, Lee JT, Nathanson KL, Medina CA, Flaherty KT, Herlyn M. Smalley KS, et al. Among authors: herlyn m. Br J Cancer. 2007 Feb 12;96(3):445-9. doi: 10.1038/sj.bjc.6603596. Epub 2007 Jan 23. Br J Cancer. 2007. PMID: 17245336 Free PMC article.

5

Identification of a novel subgroup of melanomas with KIT/cyclin-dependent kinase-4 overexpression.

Smalley KS, Contractor R, Nguyen TK, Xiao M, Edwards R, Muthusamy V, King AJ, Flaherty KT, Bosenberg M, Herlyn M, Nathanson KL. Smalley KS, et al. Among authors: herlyn m. Cancer Res. 2008 Jul 15;68(14):5743-52. doi: 10.1158/0008-5472.CAN-08-0235. Cancer Res. 2008. PMID: 18632627 Free PMC article.

6

Increased cyclin D1 expression can mediate BRAF inhibitor resistance in BRAF V600E-mutated melanomas.

Smalley KS, Lioni M, Dalla Palma M, Xiao M, Desai B, Egyhazi S, Hansson J, Wu H, King AJ, Van Belle P, Elder DE, Flaherty KT, Herlyn M, Nathanson KL. Smalley KS, et al. Among authors: herlyn m. Mol Cancer Ther. 2008 Sep;7(9):2876-83. doi: 10.1158/1535-7163.MCT-08-0431. Mol Cancer Ther. 2008. PMID: 18790768 Free PMC article.

7

CRAF inhibition induces apoptosis in melanoma cells with non-V600E BRAF mutations.

Smalley KS, Xiao M, Villanueva J, Nguyen TK, Flaherty KT, Letrero R, Van Belle P, Elder DE, Wang Y, Nathanson KL, Herlyn M. Smalley KS, et al. Among authors: herlyn m. Oncogene. 2009 Jan 8;28(1):85-94. doi: 10.1038/onc.2008.362. Epub 2008 Sep 15. Oncogene. 2009. PMID: 18794803 Free PMC article.

8

Melanoma-derived conditioned media efficiently induce the differentiation of monocytes to macrophages that display a highly invasive gene signature.

Wang T, Ge Y, Xiao M, Lopez-Coral A, Azuma R, Somasundaram R, Zhang G, Wei Z, Xu X, Rauscher FJ 3rd, Herlyn M, Kaufman RE. Wang T, et al. Among authors: herlyn m. Pigment Cell Melanoma Res. 2012 Jul;25(4):493-505. doi: 10.1111/j.1755-148X.2012.01005.x. Pigment Cell Melanoma Res. 2012. PMID: 22498258 Free PMC article.

9

Human nevi: no longer precursors of melanomas?

Zhang G, Herlyn M. Zhang G, et al. Among authors: herlyn m. J Invest Dermatol. 2012 Sep;132(9):2133-4. doi: 10.1038/jid.2012.183. J Invest Dermatol. 2012. PMID: 22895446 Free article.

10

The anti-melanoma activity of dinaciclib, a cyclin-dependent kinase inhibitor, is dependent on p53 signaling.

Desai BM, Villanueva J, Nguyen TT, Lioni M, Xiao M, Kong J, Krepler C, Vultur A, Flaherty KT, Nathanson KL, Smalley KS, Herlyn M. Desai BM, et al. Among authors: herlyn m. PLoS One. 2013;8(3):e59588. doi: 10.1371/journal.pone.0059588. Epub 2013 Mar 18. PLoS One. 2013. PMID: 23527225 Free PMC article.

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