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Nonspecificity fingerprints for clinical-stage antibodies in solution.
Herling TW, Invernizzi G, Ausserwöger H, Bjelke JR, Egebjerg T, Lund S, Lorenzen N, Knowles TPJ. Herling TW, et al. Proc Natl Acad Sci U S A. 2023 Dec 26;120(52):e2306700120. doi: 10.1073/pnas.2306700120. Epub 2023 Dec 18. Proc Natl Acad Sci U S A. 2023. PMID: 38109540
Non-specificity as the sticky problem in therapeutic antibody development.
Ausserwöger H, Schneider MM, Herling TW, Arosio P, Invernizzi G, Knowles TPJ, Lorenzen N. Ausserwöger H, et al. Among authors: herling tw. Nat Rev Chem. 2022 Dec;6(12):844-861. doi: 10.1038/s41570-022-00438-x. Epub 2022 Nov 14. Nat Rev Chem. 2022. PMID: 37117703 Review.
Surface patches induce nonspecific binding and phase separation of antibodies.
Ausserwöger H, Krainer G, Welsh TJ, Thorsteinson N, de Csilléry E, Sneideris T, Schneider MM, Egebjerg T, Invernizzi G, Herling TW, Lorenzen N, Knowles TPJ. Ausserwöger H, et al. Among authors: herling tw. Proc Natl Acad Sci U S A. 2023 Apr 11;120(15):e2210332120. doi: 10.1073/pnas.2210332120. Epub 2023 Apr 3. Proc Natl Acad Sci U S A. 2023. PMID: 37011217 Free PMC article.
ANXA11 biomolecular condensates facilitate protein-lipid phase coupling on lysosomal membranes.
Nixon-Abell J, Ruggeri FS, Qamar S, Herling TW, Czekalska MA, Shen Y, Wang G, King C, Fernandopulle MS, Sneideris T, Watson JL, Pillai VVS, Meadows W, Henderson JW, Chambers JE, Wagstaff JL, Williams SH, Coyle H, Lu Y, Zhang S, Marciniak SJ, Freund SMV, Derivery E, Ward ME, Vendruscolo M, Knowles TPJ, St George-Hyslop P. Nixon-Abell J, et al. Among authors: herling tw. bioRxiv [Preprint]. 2023 Mar 24:2023.03.22.533832. doi: 10.1101/2023.03.22.533832. bioRxiv. 2023. PMID: 36993242 Free PMC article. Preprint.
Microscale Diffusiophoresis of Proteins.
Peter QAE, Jacquat RPB, Herling TW, Challa PK, Kartanas T, Knowles TPJ. Peter QAE, et al. Among authors: herling tw. J Phys Chem B. 2022 Nov 10;126(44):8913-8920. doi: 10.1021/acs.jpcb.2c04029. Epub 2022 Oct 28. J Phys Chem B. 2022. PMID: 36306420 Free PMC article.
The binding of the small heat-shock protein αB-crystallin to fibrils of α-synuclein is driven by entropic forces.
Scheidt T, Carozza JA, Kolbe CC, Aprile FA, Tkachenko O, Bellaiche MMJ, Meisl G, Peter QAE, Herling TW, Ness S, Castellana-Cruz M, Benesch JLP, Vendruscolo M, Dobson CM, Arosio P, Knowles TPJ. Scheidt T, et al. Among authors: herling tw. Proc Natl Acad Sci U S A. 2021 Sep 21;118(38):e2108790118. doi: 10.1073/pnas.2108790118. Proc Natl Acad Sci U S A. 2021. PMID: 34518228 Free PMC article.
LAG3 is not expressed in human and murine neurons and does not modulate α-synucleinopathies.
Emmenegger M, De Cecco E, Hruska-Plochan M, Eninger T, Schneider MM, Barth M, Tantardini E, de Rossi P, Bacioglu M, Langston RG, Kaganovich A, Bengoa-Vergniory N, Gonzalez-Guerra A, Avar M, Heinzer D, Reimann R, Häsler LM, Herling TW, Matharu NS, Landeck N, Luk K, Melki R, Kahle PJ, Hornemann S, Knowles TPJ, Cookson MR, Polymenidou M, Jucker M, Aguzzi A. Emmenegger M, et al. Among authors: herling tw. EMBO Mol Med. 2021 Sep 7;13(9):e14745. doi: 10.15252/emmm.202114745. Epub 2021 Jul 26. EMBO Mol Med. 2021. PMID: 34309222 Free PMC article.
26 results