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New approach methodologies (NAMs) for human-relevant biokinetics predictions. Meeting the paradigm shift in toxicology towards an animal-free chemical risk assessment.
Punt A, Bouwmeester H, Blaauboer BJ, Coecke S, Hakkert B, Hendriks DFG, Jennings P, Kramer NI, Neuhoff S, Masereeuw R, Paini A, Peijnenburg AACM, Rooseboom M, Shuler ML, Sorrell I, Spee B, Strikwold M, Van der Meer AD, Van der Zande M, Vinken M, Yang H, Bos PMJ, Heringa MB. Punt A, et al. Among authors: heringa mb. ALTEX. 2020;37(4):607-622. doi: 10.14573/altex.2003242. Epub 2020 Jun 8. ALTEX. 2020. PMID: 32521035 Free article.
Biology-inspired microphysiological system approaches to solve the prediction dilemma of substance testing.
Marx U, Andersson TB, Bahinski A, Beilmann M, Beken S, Cassee FR, Cirit M, Daneshian M, Fitzpatrick S, Frey O, Gaertner C, Giese C, Griffith L, Hartung T, Heringa MB, Hoeng J, de Jong WH, Kojima H, Kuehnl J, Leist M, Luch A, Maschmeyer I, Sakharov D, Sips AJ, Steger-Hartmann T, Tagle DA, Tonevitsky A, Tralau T, Tsyb S, van de Stolpe A, Vandebriel R, Vulto P, Wang J, Wiest J, Rodenburg M, Roth A. Marx U, et al. Among authors: heringa mb. ALTEX. 2016;33(3):272-321. doi: 10.14573/altex.1603161. Epub 2016 May 15. ALTEX. 2016. PMID: 27180100 Free PMC article. Review.
Innovative organotypic in vitro models for safety assessment: aligning with regulatory requirements and understanding models of the heart, skin, and liver as paradigms.
Pridgeon CS, Schlott C, Wong MW, Heringa MB, Heckel T, Leedale J, Launay L, Gryshkova V, Przyborski S, Bearon RN, Wilkinson EL, Ansari T, Greenman J, Hendriks DFG, Gibbs S, Sidaway J, Sison-Young RL, Walker P, Cross MJ, Park BK, Goldring CEP. Pridgeon CS, et al. Among authors: heringa mb. Arch Toxicol. 2018 Feb;92(2):557-569. doi: 10.1007/s00204-018-2152-9. Epub 2018 Jan 23. Arch Toxicol. 2018. PMID: 29362863 Free PMC article. Review.
Next generation physiologically based kinetic (NG-PBK) models in support of regulatory decision making.
Paini A, Leonard JA, Joossens E, Bessems JGM, Desalegn A, Dorne JL, Gosling JP, Heringa MB, Klaric M, Kliment T, Kramer NI, Loizou G, Louisse J, Lumen A, Madden JC, Patterson EA, Proença S, Punt A, Setzer RW, Suciu N, Troutman J, Yoon M, Worth A, Tan YM. Paini A, et al. Among authors: heringa mb. Comput Toxicol. 2019 Feb;9:61-72. doi: 10.1016/j.comtox.2018.11.002. Comput Toxicol. 2019. PMID: 31008414 Free PMC article. Review.
Rebuttal to the letter to the editors regarding Heringa et al. (2020).
Heringa MB, Cnubben NHP, Slob W, Pronk MEJ, Muller A, Woutersen M, Hakkert BC. Heringa MB, et al. Regul Toxicol Pharmacol. 2020 Oct;116:104730. doi: 10.1016/j.yrtph.2020.104730. Epub 2020 Jul 5. Regul Toxicol Pharmacol. 2020. PMID: 32640298 No abstract available.
35 results