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Structure-Activity Relationships of Novel Thiazole-Based Modafinil Analogues Acting at Monoamine Transporters.
Kalaba P, Ilić M, Aher NY, Dragačević V, Wieder M, Zehl M, Wackerlig J, Beyl S, Sartori SB, Ebner K, Roller A, Lukic N, Beryozkina T, Gonzalez ERP, Neill P, Khan JA, Bakulev V, Leban JJ, Hering S, Pifl C, Singewald N, Lubec J, Urban E, Sitte HH, Langer T, Lubec G. Kalaba P, et al. Among authors: hering s. J Med Chem. 2020 Jan 9;63(1):391-417. doi: 10.1021/acs.jmedchem.9b01938. Epub 2019 Dec 30. J Med Chem. 2020. PMID: 31841637
Coupled and independent contributions of residues in IS6 and IIS6 to activation gating of CaV1.2.
Kudrnac M, Beyl S, Hohaus A, Stary A, Peterbauer T, Timin E, Hering S. Kudrnac M, et al. Among authors: hering s. J Biol Chem. 2009 May 1;284(18):12276-84. doi: 10.1074/jbc.M808402200. Epub 2009 Mar 5. J Biol Chem. 2009. PMID: 19265197 Free PMC article.
Significant effects are induced by either proline or threonine substitutions in the lower third of segment IIS6 ("bundle crossing region"), where S6 segments are likely to seal the channel in the closed conformation (Hohaus, A., Beyl, S., Kudrnac, M., Berjukow, S., …
Significant effects are induced by either proline or threonine substitutions in the lower third of segment IIS6 ("bundle crossing region"), …
Structural determinants of L-type channel activation in segment IIS6 revealed by a retinal disorder.
Hohaus A, Beyl S, Kudrnac M, Berjukow S, Timin EN, Marksteiner R, Maw MA, Hering S. Hohaus A, et al. Among authors: hering s. J Biol Chem. 2005 Nov 18;280(46):38471-7. doi: 10.1074/jbc.M507013200. Epub 2005 Sep 12. J Biol Chem. 2005. PMID: 16157588 Free PMC article.
The importance of a conserved isoleucine residue in the pore-lining segment IIS6 has recently been highlighted by functional analyses of a mutation (I745T) in the Ca(V)1.4 channel causing severe visual impairment (Hemara-Wahanui, A., Berjukow, S., Hope, C. I., Dearden, P. …
The importance of a conserved isoleucine residue in the pore-lining segment IIS6 has recently been highlighted by functional analyses of a m …
334 results