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Page 1
A TRPA1 inhibitor suppresses neurogenic inflammation and airway contraction for asthma treatment.
Balestrini A, Joseph V, Dourado M, Reese RM, Shields SD, Rougé L, Bravo DD, Chernov-Rogan T, Austin CD, Chen H, Wang L, Villemure E, Shore DGM, Verma VA, Hu B, Chen Y, Leong L, Bjornson C, Hötzel K, Gogineni A, Lee WP, Suto E, Wu X, Liu J, Zhang J, Gandham V, Wang J, Payandeh J, Ciferri C, Estevez A, Arthur CP, Kortmann J, Wong RL, Heredia JE, Doerr J, Jung M, Vander Heiden JA, Roose-Girma M, Tam L, Barck KH, Carano RAD, Ding HT, Brillantes B, Tam C, Yang X, Gao SS, Ly JQ, Liu L, Chen L, Liederer BM, Lin JH, Magnuson S, Chen J, Hackos DH, Elstrott J, Rohou A, Safina BS, Volgraf M, Bauer RN, Riol-Blanco L. Balestrini A, et al. Among authors: heredia je. J Exp Med. 2021 Apr 5;218(4):e20201637. doi: 10.1084/jem.20201637. J Exp Med. 2021. PMID: 33620419 Free PMC article. Clinical Trial.
The peptide symporter SLC15a4 is essential for the development of systemic lupus erythematosus in murine models.
Katewa A, Suto E, Hui J, Heredia J, Liang J, Hackney J, Anderson K, Alcantar TM, Bacarro N, Dunlap D, Eastham J, Paler-Martinez A, Rairdan XY, Modrusan Z, Lee WP, Austin CD, Lafkas D, Ghilardi N. Katewa A, et al. PLoS One. 2021 Jan 14;16(1):e0244439. doi: 10.1371/journal.pone.0244439. eCollection 2021. PLoS One. 2021. PMID: 33444326 Free PMC article.
PPAR-delta senses and orchestrates clearance of apoptotic cells to promote tolerance.
Mukundan L, Odegaard JI, Morel CR, Heredia JE, Mwangi JW, Ricardo-Gonzalez RR, Goh YP, Eagle AR, Dunn SE, Awakuni JU, Nguyen KD, Steinman L, Michie SA, Chawla A. Mukundan L, et al. Among authors: heredia je. Nat Med. 2009 Nov;15(11):1266-72. doi: 10.1038/nm.2048. Epub 2009 Oct 18. Nat Med. 2009. PMID: 19838202 Free PMC article.
Eosinophils secrete IL-4 to facilitate liver regeneration.
Goh YP, Henderson NC, Heredia JE, Red Eagle A, Odegaard JI, Lehwald N, Nguyen KD, Sheppard D, Mukundan L, Locksley RM, Chawla A. Goh YP, et al. Among authors: heredia je. Proc Natl Acad Sci U S A. 2013 Jun 11;110(24):9914-9. doi: 10.1073/pnas.1304046110. Epub 2013 May 28. Proc Natl Acad Sci U S A. 2013. PMID: 23716700 Free PMC article.
IL-4/STAT6 immune axis regulates peripheral nutrient metabolism and insulin sensitivity.
Ricardo-Gonzalez RR, Red Eagle A, Odegaard JI, Jouihan H, Morel CR, Heredia JE, Mukundan L, Wu D, Locksley RM, Chawla A. Ricardo-Gonzalez RR, et al. Among authors: heredia je. Proc Natl Acad Sci U S A. 2010 Dec 28;107(52):22617-22. doi: 10.1073/pnas.1009152108. Epub 2010 Dec 13. Proc Natl Acad Sci U S A. 2010. PMID: 21149710 Free PMC article.
TRB3 links the E3 ubiquitin ligase COP1 to lipid metabolism.
Qi L, Heredia JE, Altarejos JY, Screaton R, Goebel N, Niessen S, Macleod IX, Liew CW, Kulkarni RN, Bain J, Newgard C, Nelson M, Evans RM, Yates J, Montminy M. Qi L, et al. Among authors: heredia je. Science. 2006 Jun 23;312(5781):1763-6. doi: 10.1126/science.1123374. Science. 2006. PMID: 16794074
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