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IKAROS and MENIN coordinate therapeutically actionable leukemogenic gene expression in MLL-r acute myeloid leukemia.
Nat Cancer. 2022 May;3(5):595-613. doi: 10.1038/s43018-022-00366-1. Epub 2022 May 9.
Nat Cancer. 2022.
PMID: 35534777
Free PMC article.
The menin-MLL1 interaction is a molecular dependency in NUP98-rearranged AML.
Heikamp EB, Henrich JA, Perner F, Wong EM, Hatton C, Wen Y, Barwe SP, Gopalakrishnapillai A, Xu H, Uckelmann HJ, Takao S, Kazansky Y, Pikman Y, McGeehan GM, Kolb EA, Kentsis A, Armstrong SA.
Heikamp EB, et al. Among authors: henrich ja.
Blood. 2022 Feb 10;139(6):894-906. doi: 10.1182/blood.2021012806.
Blood. 2022.
PMID: 34582559
Free PMC article.
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Mezigdomide is effective alone and in combination with menin inhibition in preclinical models of KMT2A-r and NPM1c AML.
Bourgeois W, Cutler JA, Aubrey BJ, Wenge DV, Perner F, Martucci C, Henrich JA, Klega K, Nowak RP, Donovan KA, Boileau M, Wen Y, Hatton C, Apazidis AA, Olsen SN, Kirmani N, Pikman Y, Pollard JA, Perry JA, Sperling AS, Ebert BL, McGeehan GM, Crompton BD, Fischer ES, Armstrong SA.
Bourgeois W, et al. Among authors: henrich ja.
Blood. 2024 Apr 11;143(15):1513-1527. doi: 10.1182/blood.2023021105.
Blood. 2024.
PMID: 38096371
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